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DOI | 10.1126/science.aay8241 |
Temporal integration of mitogen history in mother cells controls proliferation of daughter cells | |
Mingwei Min; Yao Rong; Chengzhe Tian; Sabrina L. Spencer | |
2020-06-12 | |
发表期刊 | Science |
出版年 | 2020 |
英文摘要 | Classical experiments indicated that cells sense the mitogens or growth factors that control cell division within a limited window during the cell cycle. Min et al. reexamined this issue with high-throughput live-cell imaging and temporally controlled perturbations to more closely monitor dynamic signal processing. Human epithelial cells in culture integrated the mitogenic signals sensed throughout the cell cycle. One important factor was the control of translation rates, which influenced the amount of cyclin D, thus regulating proliferation. The results may also help to explain how cells maintain a uniform size. Science , this issue p. [1261][1] Multicellular organisms use mitogens to regulate cell proliferation, but how fluctuating mitogenic signals are converted into proliferation-quiescence decisions is poorly understood. In this work, we combined live-cell imaging with temporally controlled perturbations to determine the time scale and mechanisms underlying this system in human cells. Contrary to the textbook model that cells sense mitogen availability only in the G1 cell cycle phase, we find that mitogenic signaling is temporally integrated throughout the entire mother cell cycle and that even a 1-hour lapse in mitogen signaling can influence cell proliferation more than 12 hours later. Protein translation rates serve as the integrator that proportionally converts mitogen history into corresponding levels of cyclin D in the G2 phase of the mother cell, which controls the proliferation-quiescence decision in daughter cells and thereby couples protein production with cell proliferation. [1]: /lookup/doi/10.1126/science.aay8241 |
领域 | 气候变化 ; 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/274474 |
专题 | 气候变化 资源环境科学 |
推荐引用方式 GB/T 7714 | Mingwei Min,Yao Rong,Chengzhe Tian,et al. Temporal integration of mitogen history in mother cells controls proliferation of daughter cells[J]. Science,2020. |
APA | Mingwei Min,Yao Rong,Chengzhe Tian,&Sabrina L. Spencer.(2020).Temporal integration of mitogen history in mother cells controls proliferation of daughter cells.Science. |
MLA | Mingwei Min,et al."Temporal integration of mitogen history in mother cells controls proliferation of daughter cells".Science (2020). |
条目包含的文件 | 条目无相关文件。 |
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