Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

doi:10.1126/science.abb7314

GSTDTAP > 气候变化

DOI	10.1126/science.abb7314
	Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
	Barry Rockx; Thijs Kuiken; Sander Herfst; Theo Bestebroer; Mart M. Lamers; Bas B. Oude Munnink; Dennis de Meulder; Geert van Amerongen; Judith van den Brand; Nisreen M. A. Okba; Debby Schipper; Peter van Run; Lonneke Leijten; Reina Sikkema; Ernst Verschoor; Babs Verstrepen; Willy Bogers; Jan Langermans; Christian Drosten; Martje Fentener van Vlissingen; Ron Fouchier; Rik de Swart; Marion Koopmans; Bart L. Haagmans
	2020-05-29
发表期刊	Science
出版年	2020
英文摘要	We urgently need vaccines and drug treatments for coronavirus disease 2019 (COVID-19). Even under these extreme circumstances, we must have animal models for rigorous testing of new strategies. Rockx et al. have undertaken a comparative study of three human coronaviruses in cynomolgus macaques: severe acute respiratory syndrome–coronavirus (SARS-CoV) (2002), Middle East respiratory syndrome (MERS)–CoV (2012), and SARS-CoV-2 (2019), which causes COVID-19 (see the Perspective by Lakdawala and Menachery). The most recent coronavirus has a distinct tropism for the nasal mucosa but is also found in the intestinal tract. Although none of the older macaques showed the severe symptoms that humans do, the lung pathology observed was similar. Like humans, the animals shed virus for prolonged periods from their upper respiratory tracts, and like influenza but unlike the 2002 SARS-CoV, this shedding peaked early in infection. It is this cryptic virus shedding that makes case detection difficult and can jeopardize the effectiveness of isolation. Science , this issue p. [1012][1]; see also p. [942][2] The current pandemic coronavirus, severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), was recently identified in patients with an acute respiratory syndrome, coronavirus disease 2019 (COVID-19). To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or Middle East respiratory syndrome (MERS)–CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2–infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV infection, lung lesions were typically more severe, whereas they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19–like disease in macaques and provides a new model to test preventive and therapeutic strategies. [1]: /lookup/doi/10.1126/science.abb7314 [2]: /lookup/doi/10.1126/science.abc6141
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/271762
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Barry Rockx,Thijs Kuiken,Sander Herfst,et al. Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model[J]. Science,2020.
APA	Barry Rockx.,Thijs Kuiken.,Sander Herfst.,Theo Bestebroer.,Mart M. Lamers.,...&Bart L. Haagmans.(2020).Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.Science.
MLA	Barry Rockx,et al."Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model".Science (2020).