The malaria parasite has an intrinsic clock

doi:10.1126/science.aba2658

GSTDTAP > 气候变化

DOI	10.1126/science.aba2658
	The malaria parasite has an intrinsic clock
	Filipa Rijo-Ferreira; Victoria A. Acosta-Rodriguez; John H. Abel; Izabela Kornblum; Ines Bento; Gokhul Kilaru; Elizabeth B. Klerman; Maria M. Mota; Joseph S. Takahashi
	2020-05-15
发表期刊	Science
出版年	2020
英文摘要	Malarial fevers are notably regular, occurring when parasitized red blood cells rupture synchronously to release replicated parasites. It has long been speculated that the Plasmodium parasites that cause malaria must therefore have intrinsic circadian clocks to be able to synchronize like this. Two groups have now probed gene expression in experiments and models using data obtained during the developmental cycles of P. falciparum in vitro and in the mouse model of P. chabaudi malaria. Smith et al. discovered that four strains of P. falciparum have circadian and cell cycle oscillators, each with distinctive periodicities that can be experimentally manipulated. Rijo-Ferreira et al. found that gene expression in P. chabaudi was strikingly rhythmic, persisted during constant darkness and in infections of arrhythmic mice, and synchronized by entraining to the host's periodicity. Science , this issue p. [754][1], p. [746][2] Malarial rhythmic fevers are the consequence of the synchronous bursting of red blood cells (RBCs) on completion of the malaria parasite asexual cell cycle. Here, we hypothesized that an intrinsic clock in the parasite Plasmodium chabaudi underlies the 24-hour-based rhythms of RBC bursting in mice. We show that parasite rhythms are flexible and lengthen to match the rhythms of hosts with long circadian periods. We also show that malaria rhythms persist even when host food intake is evenly spread across 24 hours, suggesting that host feeding cues are not required for synchrony. Moreover, we find that the parasite population remains synchronous and rhythmic even in an arrhythmic clock mutant host. Thus, we propose that parasite rhythms are generated by the parasite, possibly to anticipate its circadian environment. [1]: /lookup/doi/10.1126/science.aba4357 [2]: /lookup/doi/10.1126/science.aba2658
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/267716
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Filipa Rijo-Ferreira,Victoria A. Acosta-Rodriguez,John H. Abel,et al. The malaria parasite has an intrinsic clock[J]. Science,2020.
APA	Filipa Rijo-Ferreira.,Victoria A. Acosta-Rodriguez.,John H. Abel.,Izabela Kornblum.,Ines Bento.,...&Joseph S. Takahashi.(2020).The malaria parasite has an intrinsic clock.Science.
MLA	Filipa Rijo-Ferreira,et al."The malaria parasite has an intrinsic clock".Science (2020).