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DOI | 10.1038/s41467-019-14099-w |
Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment | |
Cui, Yujun1; Schmid, Boris, V2; Cao, Hanli3; Dai, Xiang3; Du, Zongmin1; Easterday, W. Ryan2; Fang, Haihong1; Guo, Chenyi1; Huang, Shanqian4; Liu, Wanbing1; Qi, Zhizhen5; Song, Yajun1; Tian, Huaiyu4; Wang, Min1; Wu, Yarong1; Xu, Bing4; Yang, Chao1; Yang, Jing4; Yang, Xianwei1; Zhang, Qingwen5; Jakobsen, Kjetill S.2; Zhang, Yujiang3; Stenseth, Nils Chr2,6; Yang, Ruifu1 | |
2020-01-15 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2020 |
卷号 | 11期号:1 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; Norway |
英文摘要 | Yersinia pestis is transmitted from fleas to rodents when the bacterium develops an extensive biofilm in the foregut of a flea, starving it into a feeding frenzy, or, alternatively, during a brief period directly after feeding on a bacteremic host. These two transmission modes are in a trade-off regulated by the amount of biofilm produced by the bacterium. Here by investigating 446 global isolated Y. pestis genomes, including 78 newly sequenced isolates sampled over 40 years from a plague focus in China, we provide evidence for strong selection pressures on the RNA polymerase omega-subunit encoding gene rpoZ. We demonstrate that rpoZ variants have an increased rate of biofilm production in vitro, and that they evolve in the ecosystem during colder and drier periods. Our results support the notion that the bacterium is constantly adapting-through extended phenotype changes in the fleas-in response to climate-driven changes in the niche. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000512534100002 |
WOS关键词 | GENETIC-VARIATIONS ; GENOME SEQUENCE ; RNA-POLYMERASE ; OMEGA-SUBUNIT ; MUTATION-RATE ; RPOZ GENE ; PLAGUE ; TRANSMISSION ; DRIVEN ; LOCUS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/249918 |
专题 | 资源环境科学 |
作者单位 | 1.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China; 2.Univ Oslo, Dept Biosci, CEES, N-0316 Oslo, Norway; 3.Ctr Dis Control & Prevent Xinjiang Uygur Autonomo, Urumqi 830002, Peoples R China; 4.Beijing Normal Univ, Coll Global Change & Earth Syst Sci, State Key Lab Remote Sensing Sci, Beijing 100875, Peoples R China; 5.Qinghai Inst Endem Dis Prevent & Control, Key Lab Plague Prevent & Control Qinghai Prov, Xining 811602, Peoples R China; 6.Tsinghua Univ, Dept Earth Syst Sci, Minist Educ, Key Lab Earth Syst Modeling, Beijing 100084, Peoples R China |
推荐引用方式 GB/T 7714 | Cui, Yujun,Schmid, Boris, V,Cao, Hanli,et al. Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment[J]. NATURE COMMUNICATIONS,2020,11(1). |
APA | Cui, Yujun.,Schmid, Boris, V.,Cao, Hanli.,Dai, Xiang.,Du, Zongmin.,...&Yang, Ruifu.(2020).Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment.NATURE COMMUNICATIONS,11(1). |
MLA | Cui, Yujun,et al."Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment".NATURE COMMUNICATIONS 11.1(2020). |
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