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DOI | 10.1038/s41467-019-14042-z |
Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages | |
Mathieu, Aurelie1; Dion, Moira2,3; Deng, Ling4; Tremblay, Denise3,5; Moncaut, Elisabeth1; Shah, Shiraz A.6; Stokholm, Jakob6; Krogfelt, Karen A.7; Schjorring, Susanne7; Bisgaard, Hans6; Nielsen, Dennis S.4; Moineau, Sylvain2,3,5; Petit, Marie-Agnes1 | |
2020-01-17 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2020 |
卷号 | 11期号:1 |
文章类型 | Article |
语种 | 英语 |
国家 | France; Canada; Denmark |
英文摘要 | Bacteriophages constitute an important part of the human gut microbiota, but their impact on this community is largely unknown. Here, we cultivate temperate phages produced by 900 E. coli strains isolated from 648 fecal samples from 1-year-old children and obtain coliphages directly from the viral fraction of the same fecal samples. We find that 63% of strains hosted phages, while 24% of the viromes contain phages targeting E. coli. 150 of these phages, half recovered from strain supernatants, half from virome (73% temperate and 27% virulent) were tested for their host range on 75 E. coli strains isolated from the same cohort. Temperate phages barely infected the gut strains, whereas virulent phages killed up to 68% of them. We conclude that in fecal samples from children, temperate coliphages dominate, while virulent ones have greater infectivity and broader host range, likely playing a role in gut microbiota dynamics. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000514638400018 |
WOS关键词 | ESCHERICHIA-COLI ; HUMAN GUT ; BACTERIOPHAGES ; SOPA ; EFFECTORS ; DYNAMICS ; SEQUENCE ; VIRUSES ; PROTEIN ; VIROME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/249911 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Paris Saclay, Micalis Inst, AgroParisTech, INRAE, F-78350 Jouy En Josas, France; 2.Univ Laval, Fac Sci & Genie, Dept Biochim Microbiol & Bioinformat, Quebec City, PQ G1V 0A6, Canada; 3.Univ Laval, Fac Med Dent, Grp Rech Ecol Buccale, Quebec City, PQ G1V 0A6, Canada; 4.Univ Copenhagen, Dept Food Sci, Copenhagen, Denmark; 5.Univ Laval, Fac Med Dent, Felix Herelle Reference Ctr Bacterial Viruses, Quebec City, PQ G1V 0A6, Canada; 6.Copenhagen Univ Hosp, Copenhagen Prospect Studies Asthma Childhood, Ledreborg Alle 34, DK-2820 Gentofte, Denmark; 7.Statens Serum Inst, Dept Bacteria Parasites & Fungi, Artillerivej5, DK-2300 Copenhagen S, Denmark |
推荐引用方式 GB/T 7714 | Mathieu, Aurelie,Dion, Moira,Deng, Ling,et al. Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages[J]. NATURE COMMUNICATIONS,2020,11(1). |
APA | Mathieu, Aurelie.,Dion, Moira.,Deng, Ling.,Tremblay, Denise.,Moncaut, Elisabeth.,...&Petit, Marie-Agnes.(2020).Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages.NATURE COMMUNICATIONS,11(1). |
MLA | Mathieu, Aurelie,et al."Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages".NATURE COMMUNICATIONS 11.1(2020). |
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