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DOI | 10.1073/pnas.1921446117 |
Sexually dimorphic role of oxytocin in medaka mate choice | |
Yokoi, Saori1,2; Naruse, Kiyoshi2; Kamei, Yasuhiro2; Ansai, Satoshi2,3; Kinoshita, Masato4; Mito, Mari5; Iwasaki, Shintaro5,6; Inoue, Shuntaro1; Okuyama, Teruhiro7; Nakagawa, Shinichi1; Young, Larry J.8,9,10; Takeuchi, Hideaki3,11 | |
2020-03-03 | |
发表期刊 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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ISSN | 0027-8424 |
出版年 | 2020 |
卷号 | 117期号:9页码:4802-4808 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan; USA |
英文摘要 | Oxytocin is a central neuromodulator required for facilitating mate preferences for familiar individuals in a monogamous rodent ( prairie vole), irrespective of sex. While the role of oxytocin in mate choice is only understood in a few monogamous species, its function in nonmonogamous species, comprising the vast majority of vertebrate species, remains unclear. To address this issue, we evaluated the involvement of an oxytocin homolog (isotocin, referred herein as oxt) in mate choice in medaka fish ( Oryzias latipes). Female medaka prefer to choose familiar mates, whereas male medaka court indiscriminately, irrespective of familiarity. We generated mutants of the oxt ligand (oxt) and receptor genes (oxtr1 and oxtr2) and revealed that the oxt-oxtr1 signaling pathway was essential for eliciting female mate preference for familiar males. This pathway was also required for unrestricted and indiscriminate mating strategy in males. That is, either oxt or oxtr1 mutation in males decreased the number of courtship displays toward novel females, but not toward familiar females. Further, males with these mutations exhibited enhanced mate-guarding behaviors toward familiar females, but not toward novel females. In addition, RNA-sequencing (seq) analysis revealed that the transcription of genes involved in gamma-amino butyric acid metabolism as well as those encoding ion-transport ATPase are up-regulated in both oxt and oxtr1 mutants only in female medaka, potentially explaining the sex difference of the mutant phenotype. Our findings provide genetic evidence that oxt-oxtr1 signaling plays a role in the mate choice for familiar individuals in a sex-specific manner in medaka fish. |
英文关键词 | sexual preference mate guarding social recognition genome editing |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000518473500053 |
WOS关键词 | TARGETED MUTAGENESIS ; RECOGNITION ; BEHAVIOR ; PREFERENCES ; FAMILIARITY ; FOREBRAIN ; HORMONE ; LEADS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/249749 |
专题 | 资源环境科学 |
作者单位 | 1.Hokkaido Univ, Fac Pharmacol Sci, Sapporo, Hokkaido 0600812, Japan; 2.Natl Inst Basic Biol, Okazaki, Aichi 4448585, Japan; 3.Tohoku Univ, Grad Sch Life Sci, Sendai, Miyagi 9808577, Japan; 4.Kyoto Univ, Grad Sch Agr, Div Appl Biosci, Kyoto 6068502, Japan; 5.RIKEN, Cluster Pioneering Res, RNA Syst Biochem Lab, Wako, Saitama 3510198, Japan; 6.Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Kashiwa, Chiba 2778561, Japan; 7.Univ Tokyo, Inst Quantitat Biosci, Tokyo 1130032, Japan; 8.Univ Tsukuba, Ctr Social Neural Networks, Tsukuba, Ibaraki 3058577, Japan; 9.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Ctr Translat Social Neurosci, Atlanta, GA 30322 USA; 10.Emory Univ, Yerkes Natl Primate Res Ctr, Silvio O Conte Ctr Oxytocin & Social Cognit, Atlanta, GA 30329 USA; 11.Okayama Univ, Grad Sch Nat Sci & Technol, Okayama 7008530, Japan |
推荐引用方式 GB/T 7714 | Yokoi, Saori,Naruse, Kiyoshi,Kamei, Yasuhiro,et al. Sexually dimorphic role of oxytocin in medaka mate choice[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2020,117(9):4802-4808. |
APA | Yokoi, Saori.,Naruse, Kiyoshi.,Kamei, Yasuhiro.,Ansai, Satoshi.,Kinoshita, Masato.,...&Takeuchi, Hideaki.(2020).Sexually dimorphic role of oxytocin in medaka mate choice.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,117(9),4802-4808. |
MLA | Yokoi, Saori,et al."Sexually dimorphic role of oxytocin in medaka mate choice".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117.9(2020):4802-4808. |
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