Microbial–host molecular exchange and its functional consequences in early mammalian life

doi:10.1126/science.aba0478

GSTDTAP > 气候变化

DOI	10.1126/science.aba0478
	Microbial–host molecular exchange and its functional consequences in early mammalian life
	Stephanie C. Ganal-Vonarburg; Mathias W. Hornef; Andrew J. Macpherson
	2020-05-08
发表期刊	Science
出版年	2020
英文摘要	Molecules from symbiotic microorganisms pervasively infiltrate almost every organ system of a mammalian host, marking the initiation of microbial–host mutualism in utero, long before the newborn acquires its own microbiota. Starting from in utero development, when maternal microbial molecules can penetrate the placental barrier, we follow the different phases of adaptation through the life events of birth, lactation, and weaning, as the young mammal adapts to the microbes that colonize its body surfaces. The vulnerability of early-life mammals is mitigated by maternal detoxification and excretion mechanisms, the protective effects of maternal milk, and modulation of neonatal receptor systems. Host adaptations to microbial exposure during specific developmental windows are critical to ensure organ function for development, growth, and immunity.
领域	气候变化 ; 资源环境
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文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/249719
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Stephanie C. Ganal-Vonarburg,Mathias W. Hornef,Andrew J. Macpherson. Microbial–host molecular exchange and its functional consequences in early mammalian life[J]. Science,2020.
APA	Stephanie C. Ganal-Vonarburg,Mathias W. Hornef,&Andrew J. Macpherson.(2020).Microbial–host molecular exchange and its functional consequences in early mammalian life.Science.
MLA	Stephanie C. Ganal-Vonarburg,et al."Microbial–host molecular exchange and its functional consequences in early mammalian life".Science (2020).