Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aba0478 |
Microbial–host molecular exchange and its functional consequences in early mammalian life | |
Stephanie C. Ganal-Vonarburg; Mathias W. Hornef; Andrew J. Macpherson | |
2020-05-08 | |
发表期刊 | Science
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出版年 | 2020 |
英文摘要 | Molecules from symbiotic microorganisms pervasively infiltrate almost every organ system of a mammalian host, marking the initiation of microbial–host mutualism in utero, long before the newborn acquires its own microbiota. Starting from in utero development, when maternal microbial molecules can penetrate the placental barrier, we follow the different phases of adaptation through the life events of birth, lactation, and weaning, as the young mammal adapts to the microbes that colonize its body surfaces. The vulnerability of early-life mammals is mitigated by maternal detoxification and excretion mechanisms, the protective effects of maternal milk, and modulation of neonatal receptor systems. Host adaptations to microbial exposure during specific developmental windows are critical to ensure organ function for development, growth, and immunity. |
领域 | 气候变化 ; 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/249719 |
专题 | 气候变化 资源环境科学 |
推荐引用方式 GB/T 7714 | Stephanie C. Ganal-Vonarburg,Mathias W. Hornef,Andrew J. Macpherson. Microbial–host molecular exchange and its functional consequences in early mammalian life[J]. Science,2020. |
APA | Stephanie C. Ganal-Vonarburg,Mathias W. Hornef,&Andrew J. Macpherson.(2020).Microbial–host molecular exchange and its functional consequences in early mammalian life.Science. |
MLA | Stephanie C. Ganal-Vonarburg,et al."Microbial–host molecular exchange and its functional consequences in early mammalian life".Science (2020). |
条目包含的文件 | 条目无相关文件。 |
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