Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-020-15222-y |
Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms | |
Sun, Jian1; 39;Souza, Alaric W.2 | |
2020-03-18 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
出版年 | 2020 |
卷号 | 11期号:1 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China; USA; Spain |
英文摘要 | Anthropogenic environments have been implicated in enrichment and exchange of antibiotic resistance genes and bacteria. Here we study the impact of confined and controlled swine farm environments on temporal changes in the gut microbiome and resistome of veterinary students with occupational exposure for 3 months. By analyzing 16S rRNA and whole metagenome shotgun sequencing data in tandem with culture-based methods, we show that farm exposure shapes the gut microbiome of students, resulting in enrichment of potentially pathogenic taxa and antimicrobial resistance genes. Comparison of students' gut microbiomes and resistomes to farm workers' and environmental samples revealed extensive sharing of resistance genes and bacteria following exposure and after three months of their visit. Notably, antibiotic resistance genes were found in similar genetic contexts in student samples and farm environmental samples. Dynamic Bayesian network modeling predicted that the observed changes partially reverse over a 4-6 month period. Our results indicate that acute changes in a human's living environment can persistently shape their gut microbiota and antibiotic resistome. Environments where antibiotics are used indiscriminately exhibit microbial communities that can represent hot-spots of resistance gene enrichment, which in turn could spread to humans. Here, the authors characterize how exposure to swine farms environment lead to temporal changes in the gut microbiome and resistome of healthy veterinary students. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000522032300004 |
WOS关键词 | HOST GENOTYPE ; RESISTANCE ; RISK ; ASSOCIATION ; DIVERSITY ; STABILITY ; EVOLUTION ; BACTERIA ; PROTEIN ; GENOME |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/249666 |
专题 | 资源环境科学 |
作者单位 | 1.South China Agr Univ, Natl Risk Assessment Lab Antimicrobial Resistance, Guangzhou, Guangdong, Peoples R China; 2.Guangdong Lab Lingnan Modern Agr, Guangzhou, Guangdong, Peoples R China; 3.Washington Univ, Sch Med, Edison Family Ctr Genome Sci & Syst Biol, St Louis, MO 63130 USA; 4.Shenzhen Puensum Genetech Inst, Shenzhen, Guangdong, Peoples R China; 5.CSIC, Ctr Nacl Biotecnol, Madrid, Spain; 6.South China Agr Univ, Guangdong Prov Key Lab Vet Pharmaceut Dev & Safet, Guangzhou, Guangdong, Peoples R China; 7.Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA; 8.Washington Univ, Dept Biomed Engn, St Louis, MO 63110 USA; 9.Washington Univ, Dept Mol Microbiol, Sch Med, St Louis, MO 63110 USA |
推荐引用方式 GB/T 7714 | Sun, Jian,39;Souza, Alaric W.. Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms[J]. NATURE COMMUNICATIONS,2020,11(1). |
APA | Sun, Jian,&39;Souza, Alaric W..(2020).Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms.NATURE COMMUNICATIONS,11(1). |
MLA | Sun, Jian,et al."Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms".NATURE COMMUNICATIONS 11.1(2020). |
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