Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1038/s41467-020-15507-2 |
Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses | |
Mohammad Moniruzzaman; Carolina A. Martinez-Gutierrez; Alaina R. Weinheimer; Frank O. Aylward | |
2020-04-06 | |
发表期刊 | Nature |
出版年 | 2020 |
英文摘要 | The discovery of eukaryotic giant viruses has transformed our understanding of the limits of viral complexity, but the extent of their encoded metabolic diversity remains unclear. Here we generate 501 metagenome-assembled genomes of Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) from environments around the globe, and analyze their encoded functional capacity. We report a remarkable diversity of metabolic genes in widespread giant viruses, including many involved in nutrient uptake, light harvesting, and nitrogen metabolism. Surprisingly, numerous NCLDV encode the components of glycolysis and the TCA cycle, suggesting that they can re-program fundamental aspects of their host鈥檚 central carbon metabolism. Our phylogenetic analysis of NCLDV metabolic genes and their cellular homologs reveals distinct clustering of viral sequences into divergent clades, indicating that聽these genes are virus-specific and were acquired in the distant past. Overall our findings reveal that giant viruses encode complex metabolic capabilities with evolutionary histories largely independent of cellular life, strongly implicating them as important drivers of global biogeochemical cycles. |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/249595 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Mohammad Moniruzzaman,Carolina A. Martinez-Gutierrez,Alaina R. Weinheimer,et al. Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses[J]. Nature,2020. |
APA | Mohammad Moniruzzaman,Carolina A. Martinez-Gutierrez,Alaina R. Weinheimer,&Frank O. Aylward.(2020).Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses.Nature. |
MLA | Mohammad Moniruzzaman,et al."Dynamic genome evolution and complex virocell metabolism of globally-distributed giant viruses".Nature (2020). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论