Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP474 |
Biomonitoring in the Era of the Exposome | |
Dennis, Kristine K.1; Marder, Elizabeth1; Balshaw, David M.2; Cui, Yuxia2; Lynes, Michael A.3; Patti, Gary J.4,5; Rappaport, Stephen M.6; Shaughnessy, Daniel T.2; Vrijheid, Martine7; Barr, Dana Boyd1 | |
2017-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Spain |
英文摘要 | BACKGROUND: The term "exposome" was coined in 2005 to underscore the importance of the environment to human health and to bring research efforts in line with those on the human genome. The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts. OBJECTIVES: Our objectives were to describe why traditional and nontraditional (exposomic) biomonitoring are both critical in studies aiming to capture the exposome and to make recommendations on how to transition exposure research toward exposomic approaches. We describe the biomonitoring needs of exposome research and approaches and recommendations that will help fill the gaps in the current science. DISCUSSION: Traditional and exposomic biomonitoring approaches have key advantages and disadvantages for assessing exposure. Exposomic approaches differ from traditional biomonitoring methods in that they can include all exposures of potential health significance, whether from endogenous or exogenous sources. Issues of sample availability and quality, identification of unknown analytes, capture of nonpersistent chemicals, integration of methods, and statistical assessment of increasingly complex data sets remain challenges that must continue to be addressed. CONCLUSIONS: To understand the complexity of exposures faced throughout the lifespan, both traditional and nontraditional biomonitoring methods should be used. Through hybrid approaches and the integration of emerging techniques, biomonitoring strategies can be maximized in research to define the exposome. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397904400010 |
WOS关键词 | MASS-SPECTROMETRY ; HIGH-THROUGHPUT ; HUMAN METABOLOME ; GENE-EXPRESSION ; EXPOSURE ; DATABASE ; EPIDEMIOLOGY ; VALIDATION ; TOXICITY ; SMOKING |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24230 |
专题 | 资源环境科学 |
作者单位 | 1.Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, 1518 Clifton Rd NE,Mailstop 1518-002-2BB, Atlanta, GA 30322 USA; 2.NIEHS, Exposure Response & Technol Branch, Div Extramural Res & Training, NIH,Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA; 3.Univ Connecticut, Coll Liberal Arts & Sci, Dept Mol & Cell Biol, Storrs, CT USA; 4.Washington Univ, Dept Chem, St Louis, MO 63130 USA; 5.Washington Univ, Dept Med, St Louis, MO USA; 6.Univ Calif Berkeley, Sch Publ Hlth, Dept Environm Hlth Sci, Berkeley, CA 94720 USA; 7.Ctr Res Environm Epidemiol CREAL, Barcelona, Spain |
推荐引用方式 GB/T 7714 | Dennis, Kristine K.,Marder, Elizabeth,Balshaw, David M.,et al. Biomonitoring in the Era of the Exposome[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(4). |
APA | Dennis, Kristine K..,Marder, Elizabeth.,Balshaw, David M..,Cui, Yuxia.,Lynes, Michael A..,...&Barr, Dana Boyd.(2017).Biomonitoring in the Era of the Exposome.ENVIRONMENTAL HEALTH PERSPECTIVES,125(4). |
MLA | Dennis, Kristine K.,et al."Biomonitoring in the Era of the Exposome".ENVIRONMENTAL HEALTH PERSPECTIVES 125.4(2017). |
条目包含的文件 | 条目无相关文件。 |
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