Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1955 |
Prenatal Mancozeb Exposure, Excess Manganese, and Neurodevelopment at 1 Year of Age in the Infants' Environmental Health (ISA) Study | |
Maria Mora, Ana1,2; Cordoba, Leonel1; Camilo Cano, Juan1; Hernandez-Bonilla, David3; Pardo, Larissa1; Schnaas, Lourdes4; Smith, Donald R.5; Menezes-Filho, Jose A.6; Mergler, Donna7; Lindh, Christian H.8; Eskenazi, Brenda2; van Wendel de Joode, Berna1 | |
2018-05-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:5 |
文章类型 | Article |
语种 | 英语 |
国家 | Costa Rica; USA; Mexico; Brazil; Canada; Sweden |
英文摘要 | BACKGROUND: Although growing evidence suggests that early-life excess manganese (Mn) impairs neurodevelopment, data on the neurodevelopmental effects of mancozeb, a fungicide containing Mn, and its main metabolite ethylenethiourea (ETU) are limited. OBJECTIVE: We examined whether prenatal mancozeb exposure and excess Mn were associated with neurodevelopment in 355 1-y-old infants living near banana plantations with frequent aerial mancozeb spraying in Costa Rica. METHODS: We measured urinary ETU, hair Mn, and blood Mn concentrations in samples collected 1-3 times during pregnancy from mothers enrolled in the Infants' Environmental Health (ISA) study. We then assessed neurodevelopment in their 1-y-old infants using the Bayley Scales of Infant and Toddler Development, 3rd edition (BSID-III). We estimated exposure-outcome associations using linear regression models adjusted for maternal education, parity, gestational age at birth, child age, Home Observation for Measurement of the Environment score, and location of neurodevelopmental assessment. RESULTS: Median (P25-P75) urinary ETU, hair Mn, and blood Mn measured during pregnancy were 3: 3 mu g= L (2.4-4.9; specific gravity-corrected), 1: 7 lg= g (0.9-4.1), and 24: 0 mu g= L (20.3-28.0), respectively. Among girls, higher ETU was associated with lower social-emotional scores [b per 10-fold increase= -7: 4 points (95% CI: -15: 2, 0.4)], whereas higher hair Mn was associated with lower cognitive scores [-3: 0 (-6: 1, 0.1)]. Among boys, higher hair Mn was associated with lower social-emotional scores [-4: 6 (-8: 5, -0: 8)]. We observed null associations for blood Mn, language, and motor outcomes. CONCLUSIONS: Our findings indicate that maternal exposure to mancozeb and excess Mn during pregnancy may have adverse and sex-specific effects on infant neurodevelopment. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000433628200001 |
WOS关键词 | BLOOD MANGANESE ; INTELLECTUAL FUNCTION ; HAIR MANGANESE ; PREGNANT-WOMEN ; DRINKING-WATER ; COSTA-RICA ; CHILDREN ; LEAD ; PESTICIDES ; GENDER |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24222 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Nacl, Cent Amer Inst Studies Tox Subst IRET, POB 86-3000, Heredia, Costa Rica; 2.Univ Calif Berkeley, Sch Publ Hlth, CERCH, Berkeley, CA 94720 USA; 3.Natl Inst Publ Hlth, Environm Hlth Dept, Mexico City, DF, Mexico; 4.Natl Inst Perinatol, Div Res Community Intervent, Mexico City, DF, Mexico; 5.Univ Calif Santa Cruz, Dept Microbiol & Environm Toxicol, Santa Cruz, CA 95064 USA; 6.Univ Fed Bahia, Fac Pharm, Salvador, BA, Brazil; 7.Univ Quebec, Ctr Interdisciplinary Res, Ctr Hlth Well Being Soc & Environm CINBIOSE, Montreal, PQ, Canada; 8.Lund Univ, Inst Lab Med, Div Occupat & Environm Med, Lund, Sweden |
推荐引用方式 GB/T 7714 | Maria Mora, Ana,Cordoba, Leonel,Camilo Cano, Juan,et al. Prenatal Mancozeb Exposure, Excess Manganese, and Neurodevelopment at 1 Year of Age in the Infants' Environmental Health (ISA) Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(5). |
APA | Maria Mora, Ana.,Cordoba, Leonel.,Camilo Cano, Juan.,Hernandez-Bonilla, David.,Pardo, Larissa.,...&van Wendel de Joode, Berna.(2018).Prenatal Mancozeb Exposure, Excess Manganese, and Neurodevelopment at 1 Year of Age in the Infants' Environmental Health (ISA) Study.ENVIRONMENTAL HEALTH PERSPECTIVES,126(5). |
MLA | Maria Mora, Ana,et al."Prenatal Mancozeb Exposure, Excess Manganese, and Neurodevelopment at 1 Year of Age in the Infants' Environmental Health (ISA) Study".ENVIRONMENTAL HEALTH PERSPECTIVES 126.5(2018). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论