Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2754 |
Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort | |
Liew, Zeyan1; Ritz, Beate1,2,3; Bach, Cathrine Carlsen4,5; Asarnow, Robert F.6,7; Bech, Bodil Hammer8; Nohr, Ellen A.9; Bossi, Rossana10; Henriksen, Tine Brink5; Bonefeld-Jorgensen, Eva Cecilie11,12; Olsen, Jorn1,8,13 | |
2018-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark; Greenland |
英文摘要 | BACKGROUND: Perfluoroalkyl substances (PFASs) are widespread persistent organic compounds that have been suggested to affect neurodevelopment. OBJECTIVE: We aimed to evaluate whether prenatal exposure to PFASs is associated with IQ in children. METHODS: We studied 1,592 pregnancies enrolled in the Danish National Birth Cohort (DNBC) during 1996-2002. Sixteen PFASs were measured in maternal plasma collected in early gestation. Child IQ was assessed at 5 y of age using the Wechsler Primary and Preschool Scales of Intelligence Revised (WPPSI-R) administered by trained psychologists. Using multivariable linear regression models, we estimated the differences in child IQ scores according to PFAS concentration [per natural-log (ng/mL) unit increase or values categorized in quartiles]. RESULTS: Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were detected in all samples, and live additional PFASs were quantified in >80% of the samples. Overall, we found no strong associations between a natural-log unit increase in each of the seven PFASs we evaluated and child IQ scores. A few positive and negative associations were found in the sex-stratified PFAS quartile analyses, hut the patterns were inconsistent. CONCLUSION: Overall, we did not find consistent evidence to suggest prenatal exposure to PFASs to be associated with child IQ scores at 5 y of age in the DNBC. Some of the sex-specific observations warrant further investigation. Additional studies should examine offspring IQ at older ages and assess other functional cognitive and neuropsychiaffic measures in addition to intelligence. Postnatal exposures to PFASs and mixture effects for PFASs and PFASs with other environmental pollutants should also be considered in future research. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438820100008 |
WOS关键词 | ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; LEVEL LEAD-EXPOSURE ; THYROID-HORMONE ; POLYFLUOROALKYL SUBSTANCES ; EARLY-PREGNANCY ; FOLLOW-UP ; CEREBRAL-PALSY ; DRINKING-WATER ; INFANT COHORT ; CHILDRENS IQ |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24221 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA; 2.Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA USA; 3.Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA USA; 4.Randers Reg Hosp, Dept Pediat & Adolescent Med, Randers, Denmark; 5.Aarhus Univ Hosp, Dept Pediat & Adolescent Med, Skejby, Denmark; 6.Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA; 7.Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA; 8.Univ Aarhus, Dept Publ Hlth, Sect Epidemiol, Aarhus, Denmark; 9.Univ Southern Denmark, Dept Clin Res, Res Unit Gynaecol & Obestet, Odense, Denmark; 10.Univ Aarhus, Dept Environm Sci, Roskilde, Denmark; 11.Aarhus Univ, Ctr Arctic Hlth & Mol Epidemiol, Dept Publ Hlth, Aarhus, Denmark; 12.Univ Greenland, Greenland Ctr Hlth Res, Ilisimatusarfik, Nuuk, Greenland; 13.Aarhus Univ Hosp, Dept Clin Epidemiol, Skejby, Denmark |
推荐引用方式 GB/T 7714 | Liew, Zeyan,Ritz, Beate,Bach, Cathrine Carlsen,et al. Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(6). |
APA | Liew, Zeyan.,Ritz, Beate.,Bach, Cathrine Carlsen.,Asarnow, Robert F..,Bech, Bodil Hammer.,...&Olsen, Jorn.(2018).Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort.ENVIRONMENTAL HEALTH PERSPECTIVES,126(6). |
MLA | Liew, Zeyan,et al."Prenatal Exposure to Perfluoroalkyl Substances and IQ Scores at Age 5; a Study in the Danish National Birth Cohort".ENVIRONMENTAL HEALTH PERSPECTIVES 126.6(2018). |
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