Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP353 |
Levels and Determinants of DDT and DDE Exposure in the VHEMBE Cohort | |
Gaspar, Fraser W.1; Chevrier, Jonathan2; Quiros-Alcala, Lesliam1,3; Lipsitt, Jonah M.1; Barr, Dana Boyd4,5; Holland, Nina1; Bornman, Riana6,7,8; Eskenazi, Brenda1 | |
2017-07-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:7 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada; South Africa |
英文摘要 | BACKGROUND: Although indoor residual spraying (IRS) is an effective tool for malaria control, its use contributes to high insecticide exposure in sprayed communities and raises concerns about possible unintended health effects. OBJECTIVE: The Venda Health Examination of Mothers, Babies and their Environment (VHEMBE) is a birth cohort study initiated in 2012 to characterize prenatal exposure to IRS insecticides and exposures' impacts on child health and development in rural South Africa. METHODS: In this report, we describe the VHEMBE cohort and dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) serum concentrations measured in VHEMBE mothers when they presented for delivery. In addition, we applied a causal inference framework to estimate the potential reduction in population-level p,p'-DDT and p,p'-DDE serum concentrations under five hypothetical interventions. A total of 751 mothers were enrolled. RESULTS: Serum concentrations of p,p' isomers of DDT and DDE were above the limit of detection (LOD) in >= 98% of the samples, whereas the o,p' isomers were above the LOD in at least 80% of the samples. Median (interquartile range) p,p'-DDT and p,p'-DDE serum concentrations for VHEMBE cohort participants were 55.3 (19.0-259.3) and 242.2 (91.8-878.7) ng/g-lipid, respectively. Mothers reporting to have lived in a home sprayed with DDT for malaria control had similar to 5-7 times higher p,p'-DDT and p,p'-DDE serum concentrations than those who never lived in a home sprayed with DDT. Of the five potential interventions tested, we found increasing access to water significantly reduced p,p'-DDT exposure and increasing the frequency of household wet mopping significantly reduced p,p'-DDT and p,p'-DDE exposure. CONCLUSION: Our findings suggest that several intervention approaches may reduce DDT/DDE exposure in pregnant women living in IRS communities. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413791300014 |
WOS关键词 | SOUTH-AFRICA ; MALARIA CONTROL ; BREAST-MILK ; ORGANOCHLORINE PESTICIDES ; PYRETHROID RESIDUES ; RELATIVE VALIDATION ; HUMAN-SERUM ; AREA ; CHILDREN ; WOMEN |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24205 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif Berkeley, Sch Publ Hlth, CERCH, Berkeley, CA 94720 USA; 2.McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada; 3.Univ Maryland, Sch Publ Hlth, Maryland Inst Appl Environm Hlth, College Pk, MD 20742 USA; 4.Emory Univ, Dept Environm Hlth, Atlanta, GA 30322 USA; 5.Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA; 6.Univ Pretoria, Dept Urol, Pretoria, South Africa; 7.Univ Pretoria, Ctr Sustainable Malaria Control, Pretoria, South Africa; 8.Univ Pretoria, Sch Hlth Syst & Publ Hlth, Pretoria, South Africa |
推荐引用方式 GB/T 7714 | Gaspar, Fraser W.,Chevrier, Jonathan,Quiros-Alcala, Lesliam,et al. Levels and Determinants of DDT and DDE Exposure in the VHEMBE Cohort[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(7). |
APA | Gaspar, Fraser W..,Chevrier, Jonathan.,Quiros-Alcala, Lesliam.,Lipsitt, Jonah M..,Barr, Dana Boyd.,...&Eskenazi, Brenda.(2017).Levels and Determinants of DDT and DDE Exposure in the VHEMBE Cohort.ENVIRONMENTAL HEALTH PERSPECTIVES,125(7). |
MLA | Gaspar, Fraser W.,et al."Levels and Determinants of DDT and DDE Exposure in the VHEMBE Cohort".ENVIRONMENTAL HEALTH PERSPECTIVES 125.7(2017). |
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