Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP424 |
Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge | |
Stone, Vicki1; Miller, Mark R.2; Clift, Martin J. D.3,4; Elder, Alison5; Mills, Nicholas L.2; Moller, Peter6; Schins, Roel P. F.7; Vogel, Ulla8,9; Kreyling, Wolfgang G.10; Jensen, Keld Alstrup8; Kuhlbusch, Thomas A. J.11,12; Schwarze, Per E.13; Hoet, Peter14; Pietroiusti, Antonio15; De Vizcaya-Ruiz, Andrea16; Baeza-Squiban, Armelle17; Teixeira, Joao Paulo18,19; Lang Tran, C.20; Cassee, Flemming R.21,22 | |
2017-10-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:10 |
文章类型 | Review |
语种 | 英语 |
国家 | Scotland; Switzerland; Wales; USA; Denmark; Germany; Norway; Belgium; Italy; Mexico; France; Portugal; Netherlands |
英文摘要 | BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultraline (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP. METHODS: A workshop of experts systematically analyzed the available information and identified 19 key lessons that can facilitate knowledge exchange between these discipline areas. DISCUSSION: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment to understanding and defining dose and the molecular mechanisms of toxicity. This review identities a number of key areas in which additional research prioritization would facilitate both research fields simultaneously. CONCLUSION: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413793300012 |
WOS关键词 | PARTICULATE AIR-POLLUTION ; DIESEL-EXHAUST INHALATION ; HEART-RATE-VARIABILITY ; ACUTE-PHASE RESPONSE ; INSOLUBLE IRIDIUM PARTICLES ; SURFACE-AREA CONCENTRATIONS ; CARDIAC OXIDATIVE STRESS ; IN-VITRO ; CARBON-BLACK ; ENGINEERED NANOMATERIALS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24186 |
专题 | 资源环境科学 |
作者单位 | 1.Heriot Watt Univ, Inst Biol Chem Biophys & Bioengn, Edinburgh, Midlothian, Scotland; 2.Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland; 3.Univ Fribourg, Adolphe Merkle Inst, Fribourg, Switzerland; 4.Swansea Univ, Med Sch, Swansea, W Glam, Wales; 5.Univ Rochester, Med Ctr, Rochester, NY 14642 USA; 6.Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark; 7.IUF Leibniz Inst Umweltmed Forsch, Dusseldorf, Germany; 8.Natl Res Ctr Working Environm, Copenhagen, Denmark; 9.Tech Univ Denmark, Dept Micro & Nanotechnol, Lyngby, Denmark; 10.German Res Ctr Environm Hlth GmbH, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany; 11.Inst Energie & Umwelttech eV IUTA, Air Qual & Sustainable Nanotechnol Unit, Duisburg, Germany; 12.Fed Inst Occupat Safety & Hlth, Duisburg, Germany; 13.Norwegian Inst Publ Hlth, Oslo, Norway; 14.Katholieke Univ Leuven, Ctr Environm & Hlth, Leuven, Belgium; 15.Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy; 16.Natl Polytech Inst, IPN, CINVESTAV, Dept Toxicol,Ctr Res & Adv Studies, Mexico City, DF, Mexico; 17.Paris Diderot Univ, Paris, France; 18.Natl Inst Hlth, Oporto, Portugal; 19.Univ Porto, Inst Saude Publ Univ Porto Epidemiol ISPUP EPI Un, Oporto, Portugal; 20.Inst Occupat Med, Edinburgh, Midlothian, Scotland; 21.Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands; 22.Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands |
推荐引用方式 GB/T 7714 | Stone, Vicki,Miller, Mark R.,Clift, Martin J. D.,et al. Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(10). |
APA | Stone, Vicki.,Miller, Mark R..,Clift, Martin J. D..,Elder, Alison.,Mills, Nicholas L..,...&Cassee, Flemming R..(2017).Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge.ENVIRONMENTAL HEALTH PERSPECTIVES,125(10). |
MLA | Stone, Vicki,et al."Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge".ENVIRONMENTAL HEALTH PERSPECTIVES 125.10(2017). |
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