Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP3567 |
Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort | |
Ernst, Andreas1,2; Brix, Nis1,2; Lauridsen, Lea Lykke Braskhoj1; Olsen, Jorn2,3; Parner, Erik Thorup4; Liew, Zeyan5,6; Olsen, Lars Henning7; Ramlau-Hansen, Cecilia Host1 | |
2019 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:1 |
文章类型 | Article |
语种 | 英语 |
国家 | Denmark; USA |
英文摘要 | BACKGROUND: It remains unsettled whether prenatal exposure to perfluoroalkyl substances (PFASs) affects human reproductive health through potential endocrine disruption. OBJECTIVES: We aimed to explore the associations between prenatal exposure to several PFASs and various aspects of pubertal development boys and girls. METHODS: We studied two samples (n = 722 and 445) hum the Puberty Cohort, nested within the Danish National Birth Cohort (DNBC), measuring PEAS in maternal plasma hum early gestation. Data on pubertal development were collected biannually from the age of 11 y until full maturation, using web-based questionnaires. Outcomes were age at menarche, voice break, first ejaculation, and Tanner stages 2 to 5 for pubic hair, breast, genital development, and a combined puberty indicator. A regression model for censored data was used to estimate mean difference (months) in age at achieving the pubertal outcomes across tertiles of PEAS concentrations and with a doubling of PFAS concentrations (continuous). For perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), a meta-analysis was used to provide a weighted average of the point estimates from samples 1 and 2. RESULTS: Overall, prenatal exposure to PFOS, perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PDFA) (girls) and PFHxS and PFHpS (boys) was associated with lower mean age at puberty marker onset. PFDA and PFNA exposure was associated with higher mean age at onset of puberty in boys. Nonmonotonic associations in girls (PFOS, PFHpS, PFDA) and boys (PFDA, PFNA) were observed, showing larger mean age differences for the combined puberty indicator in the middle tertile [girls: PFOS: -3.73 mo, 95% confidence interval (CI): -6.59, -0.87; PFHpS: -4.92 mo, 95% CI: -11.68, 1.85; PFDA: -3.60 mo, 95% CI: -9.03, 1.83; and boys: PFNA: 4.45 mo, 95% CL -1.30, 10.2E PFDA: 4.59 mo, 95% CL -0.93, 10.11] than in the highest tertile with the lowest as reference. CONCLUSIONS: Our population-based cohort study suggests sex-specific associations of altered pubertal development with prenatal exposure to PFASs. These findings are novel, and replication is needed. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000457877000005 |
WOS关键词 | PERFLUOROOCTANE SULFONATE PFOS ; PRENATAL EXPOSURE ; PERFLUORINATED CHEMICALS ; POLYFLUOROALKYL SUBSTANCES ; REPRODUCTIVE HORMONES ; PREGNANCY ; AGE ; HEALTH ; ACIDS ; ASSOCIATION |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24171 |
专题 | 资源环境科学 |
作者单位 | 1.Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Bartholins Alle 2, DK-8000 Aarhus C, Denmark; 2.Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA; 3.Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark; 4.Aarhus Univ, Sect Biostat, Dept Publ Hlth, Aarhus, Denmark; 5.Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA; 6.Yale Sch Publ Hlth, Yale Ctr Perinatal Pediat & Environm Epidemiol, New Haven, CT USA; 7.Aarhus Univ Hosp, Sect Paediat Urol, Dept Urol, Aarhus, Denmark |
推荐引用方式 GB/T 7714 | Ernst, Andreas,Brix, Nis,Lauridsen, Lea Lykke Braskhoj,et al. Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(1). |
APA | Ernst, Andreas.,Brix, Nis.,Lauridsen, Lea Lykke Braskhoj.,Olsen, Jorn.,Parner, Erik Thorup.,...&Ramlau-Hansen, Cecilia Host.(2019).Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort.ENVIRONMENTAL HEALTH PERSPECTIVES,127(1). |
MLA | Ernst, Andreas,et al."Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort".ENVIRONMENTAL HEALTH PERSPECTIVES 127.1(2019). |
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