Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4555 |
A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing | |
Patlewicz, Grace1; Richard, Ann M.1; Williams, Antony J.1; Grulke, Christopher M.1; Sams, Reeder1; Lambert, Jason2; Noyes, Pamela D.3; DeVito, Michael J.4; Hines, Ronald N.5; Strynar, Mark6; Guiseppi-Elie, Annette6; Thomas, Russell S.1 | |
2019 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:1 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Per- and polyfluoroalkyl substances (PFASs) are a group of fluorinated substances of interest to researchers, regulators, and the public due to their widespread presence in the environment. A few PFASs have comparatively extensive amounts of human epidemiological, exposure, and experimental animal toxicity data (e.g., perfluorooctanoic acid), whereas little toxicity and exposure information exists for much of the broader set of PFASs. Given that traditional approaches to generate toxicity information are resource intensive, new approach methods, including in vitro high throughput toxicity (HTT) testing, are being employed to inform PFAS hazard characterization and further (in vivo) testing. The U.S. Environmental Protection Agency (EPA) and the National Toxicology Program (NIP) are collaborating to develop a risk-based approach for conducting PFAS toxicity testing to facilitate PFAS human health assessments. This article descrihes the construction of a PFAS screening library and the process by which a targeted subset of 75 PFASs were selected. Multiple factors were considered, including interest to the U.S. EPA, compounds within targeted categories, structural diversity, exposure considerations, procurability and testability, and availability of existing toxicity data. Generating targeted HTT data for PFASs represents a new frontier for informing priority setting. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000457877000009 |
WOS关键词 | PERFLUOROALKYL ; TECHNOLOGIES ; ENVIRONMENT ; MODEL |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24170 |
专题 | 资源环境科学 |
作者单位 | 1.US EPA, Natl Ctr Computat Toxicol, ORD, Res Triangle Pk, NC 27711 USA; 2.US EPA, NCEA, ORD, Cincinnati, OH 45268 USA; 3.US EPA, Integrated Risk Informat Syst Div, NCEA, ORD, Washington, DC 20460 USA; 4.NIEHS, Natl Toxicol Program, NIH, US Dept HHS, POB 12233, Res Triangle Pk, NC 27709 USA; 5.US EPA, Natl Hlth & Environm Effects Res Lab, ORD, Res Triangle Pk, NC 27711 USA; 6.US EPA, Natl Exposure Res Lab, ORD, Res Triangle Pk, NC 27711 USA |
推荐引用方式 GB/T 7714 | Patlewicz, Grace,Richard, Ann M.,Williams, Antony J.,et al. A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(1). |
APA | Patlewicz, Grace.,Richard, Ann M..,Williams, Antony J..,Grulke, Christopher M..,Sams, Reeder.,...&Thomas, Russell S..(2019).A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing.ENVIRONMENTAL HEALTH PERSPECTIVES,127(1). |
MLA | Patlewicz, Grace,et al."A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing".ENVIRONMENTAL HEALTH PERSPECTIVES 127.1(2019). |
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