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DOI | 10.1289/EHP464 |
Monoethylhexyl Phthalate Elicits an Inflammatory Response in Adipocytes Characterized by Alterations in Lipid and Cytokine Pathways | |
Manteiga, Sara; Lee, Kyongbum | |
2017-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: A growing body of evidence links endocrine-disrupting chemicals (EDCs) with obesity-related metabolic diseases. While it has been shown that EDCs can predispose individuals toward adiposity by affecting developmental processes, little is known about the chemicals' effects on adult adipose tissue. OBJECTIVES: Our aim was to study the effects of low, physiologically relevant doses of EDCs on differentiated murine adipocytes. METHODS: We combined metabolomics, proteomics, and gene expression analysis to characterize the effects of mono-ethylhexyl phthalate (MEHP) in differentiated adipocytes. Results: Repeated exposure to MEHP over several days led to changes in metabolite and enzyme levels indicating elevated lipogenesis and lipid oxidation. The chemical exposure also increased expression of major inflammatory cytokines, including chemotactic factors. Proteomic and gene expression analysis revealed significant alterations in pathways regulated by peroxisome proliferator activated receptor-gamma(PPAR gamma). Inhibiting the nuclear receptor's activity using a chemical antagonist abrogated not only the alterations in PPAR gamma-regulated metabolic pathways, but also the increases in cytokine expression. CONCLUSIONS: Our results show that MEHP can induce a pro-inflammatory state in differentiated adipocytes. This effect is at least partially mediated PPAR gamma. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397904400023 |
WOS关键词 | MIGRATION INHIBITORY FACTOR ; MACROPHAGE-MIGRATION ; BISPHENOL-A ; PERINATAL EXPOSURE ; ADIPOSE-TISSUE ; ADIPOGENESIS ; OBESITY ; METABOLITES ; ACTIVATION ; PROTEINS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24166 |
专题 | 资源环境科学 |
作者单位 | Tufts Univ, Dept Chem & Biol Engn, Medford, MA 02155 USA |
推荐引用方式 GB/T 7714 | Manteiga, Sara,Lee, Kyongbum. Monoethylhexyl Phthalate Elicits an Inflammatory Response in Adipocytes Characterized by Alterations in Lipid and Cytokine Pathways[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(4). |
APA | Manteiga, Sara,&Lee, Kyongbum.(2017).Monoethylhexyl Phthalate Elicits an Inflammatory Response in Adipocytes Characterized by Alterations in Lipid and Cytokine Pathways.ENVIRONMENTAL HEALTH PERSPECTIVES,125(4). |
MLA | Manteiga, Sara,et al."Monoethylhexyl Phthalate Elicits an Inflammatory Response in Adipocytes Characterized by Alterations in Lipid and Cytokine Pathways".ENVIRONMENTAL HEALTH PERSPECTIVES 125.4(2017). |
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