Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP316 |
Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model | |
Duval, Caroline1,2; Teixeira-Clerc, Fatima3,4; Leblanc, Alix F.1,2; Touch, Sothea5,6; Emond, Claude7; Guerre-Millo, Michele5,6; Lotersztajn, Sophie3,4; Barouki, Robert1,2,8; Aggerbeck, Martine1,2; Coumoul, Xavier1,2 | |
2017-03-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:3 |
文章类型 | Article |
语种 | 英语 |
国家 | France; Canada |
英文摘要 | BACKGROUND: Exposure to persistent organic pollutants (POPs) has been associated with the progression of chronic liver diseases, yet the contribution of POPs to the development of fibrosis in non-alcoholic fatty liver disease (NAFLD), a condition closely linked to obesity, remains poorly documented. OBJECTIVES: We investigated the effects of subchronic exposure to low doses of the POP 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), an aryl hydrocarbon receptor ligand, on NAFLD progression in diet-induced obese C57BL/6J mice. METHODS: Male C57BL/6J mice were fed either a 10% low-fat (LFD) or a 45% high-fat (HFD) purified diet for 14 weeks and TCDD-exposed groups were injected once a week with 5 mu g/kg TCDD or the vehicle for the last 6 weeks of the diet. RESULTS: Liver histology and triglyceride levels showed that exposure of HFD fed mice to TCDD worsened hepatic steatosis, as compared to either HFD alone or LFD plus TCDD and the mRNA levels of key genes of hepatic lipid metabolism were strongly altered in co-treated mice. Further, increased liver collagen staining and serum transaminase levels showed that TCDD induced liver fibrosis in the HFD fed mice. TCDD in LFD fed mice increased the expression of several inflammation and fibrosis marker genes with no additional effect from a HFD. CONCLUSIONS: Exposure to TCDD amplifies the impairment of liver functions observed in mice fed an enriched fat diet as compared to a low fat diet. The results provide new evidence that environmental pollutants promote the development of liver fibrosis in obesity-related NAFLD in C57BL/6J mice. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000395714400025 |
WOS关键词 | ARYL-HYDROCARBON RECEPTOR ; HEPATIC GENE-EXPRESSION ; PERSISTENT ORGANIC POLLUTANTS ; FATTY LIVER ; NONALCOHOLIC STEATOHEPATITIS ; TRIGLYCERIDE SYNTHESIS ; GLUCOSE-METABOLISM ; INSULIN-RESISTANCE ; MICE ; DISEASE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24090 |
专题 | 资源环境科学 |
作者单位 | 1.INSERM UMR, S1124, Paris, France; 2.Univ Paris 05, ComUE Communaute Univ & Etablissements, Sorbonne Paris Cite, Paris, France; 3.Hop Henri Mondor, INSERM UMR S955, Creteil, France; 4.Univ Paris Est, Creteil, France; 5.INSERM UMR S1166, Paris, France; 6.Univ Paris 06, Paris, France; 7.Univ Montreal, Sch Publ Hlth, Dept Environm & Occupat Hlth, Montreal, PQ, Canada; 8.Hop Necker Enfants Malad, AP HP, Paris, France |
推荐引用方式 GB/T 7714 | Duval, Caroline,Teixeira-Clerc, Fatima,Leblanc, Alix F.,et al. Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(3). |
APA | Duval, Caroline.,Teixeira-Clerc, Fatima.,Leblanc, Alix F..,Touch, Sothea.,Emond, Claude.,...&Coumoul, Xavier.(2017).Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model.ENVIRONMENTAL HEALTH PERSPECTIVES,125(3). |
MLA | Duval, Caroline,et al."Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model".ENVIRONMENTAL HEALTH PERSPECTIVES 125.3(2017). |
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