Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP631 |
Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study | |
Rahman, Syed Moshfiqur1,2; Kippler, Maria1; Tofail, Fahmida2; Bolte, Sven3,4; Hamadani, Jena Derakhshani2; Vahter, Marie1 | |
2017-05-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:5 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; Bangladesh |
英文摘要 | BACKGROUND: Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. OBJECTIVES: We prospectively evaluated the effects of W-Mn, from fetal life to school age, on childrens cognitive abilities and behavior. METHODS: We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry. RESULTS: The median W-Mn was 0.20 mg/L (range 0.0016.6) during pregnancy and 0.34mg/L (<0.0018.7) at 10 y. In multivariable-adjusted linear regression analyses, restricted to children with low arsenic (As) exposure, none of the W-Mn exposures was associated with the childrens cognitive abilities. Stratifying by gender (p for interaction in general <0.081) showed that prenatal W-Mn (<3 mg/L) was positively associated with cognitive ability measures in girls but not in boys. W-Mn at all time points was associated with an increased risk of conduct problems, particularly in boys (range 2443% per mg/L). At the same time, the prenatal W-Mn was associated with a decreased risk of emotional problems [odds ratio (OR)=0.39 (95% CI: 0.19, 0.82)] in boys. In girls, W-Mn was mainly associated with low prosocial scores [prenatal W-Mn: OR=1.48 (95% CI: 1.06, 1.88)]. CONCLUSIONS: Elevated prenatal W-Mn exposure was positively associated with cognitive function in girls, whereas boys appeared to be unaffected. Early life W-Mn exposure appeared to adversely affect childrens behavior. https://doi.org/10.1289/EHP631 |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413786500004 |
WOS关键词 | RURAL BANGLADESH ; INTELLECTUAL FUNCTION ; ARSENIC EXPOSURE ; EARLY-LIFE ; CHILDREN ; POPULATION ; PREGNANCY ; HEALTH ; BIRTH ; LEVEL |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24084 |
专题 | 资源环境科学 |
作者单位 | 1.Karolinska Inst, Inst Environm Med, Box 210, SE-17177 Stockholm, Sweden; 2.Int Ctr Diarrhoeal Dis Res Bangladesh Icddr b, Dhaka, Bangladesh; 3.Karolinska Inst, Dept Womens & Childrens Hlth, Pediat Neuropsychiat Unit, Ctr Neurodev Disorders KIND, Stockholm, Sweden; 4.Stockholm Cty Council, Ctr Psychiat Res, Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Rahman, Syed Moshfiqur,Kippler, Maria,Tofail, Fahmida,et al. Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(5). |
APA | Rahman, Syed Moshfiqur,Kippler, Maria,Tofail, Fahmida,Bolte, Sven,Hamadani, Jena Derakhshani,&Vahter, Marie.(2017).Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(5). |
MLA | Rahman, Syed Moshfiqur,et al."Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.5(2017). |
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