Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP258 |
Early Postnatal Manganese Exposure Causes Lasting Impairment of Selective and Focused Attention and Arousal Regulation in Adult Rats | |
Beaudin, Stephane A.1; Strupp, Barbara J.2,3; Strawderman, Myla2; Smith, Donald R.1 | |
2017-02-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:2 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Studies in children and adolescents have associated early developmental manganese (Mn) exposure with inattention, impulsivity, hyperactivity, and oppositional behaviors, but causal inferences are precluded by the correlational nature of the data and generally limited control for potential confounders. OBJECTIVES: To determine whether early postnatal oral Mn exposure causes lasting attentional and impulse control deficits in adulthood, and whether continued lifelong Mn exposure exacerbates these effects, using a rat model of environmental Mn exposure. METHODS: Neonates were exposed orally to 0, 25 or 50 mg Mn/kg/day during early postnatal life (PND 1-21) or throughout life from PND 1 until the end of the study. In adulthood, the animals were tested on a series of learning and attention tasks using the five-choice serial reaction time task. RESULTS: Early postnatal Mn exposure caused lasting attentional dysfunction due to impairments in attentional preparedness, selective attention, and arousal regulation, whereas associative ability (learning) and impulse control were spared. The presence and severity of these deficits varied with the dose and duration of Mn exposure. CONCLUSIONS: This study is the first to show that developmental Mn exposure can cause lasting impairments in focused and selective attention and arousal regulation, and to identify the specific nature of the impairments. Given the importance of attention and arousal regulation in cognitive functioning, these findings substantiate concerns about the adverse effects of developmental Mn exposure in humans. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000394004000017 |
WOS关键词 | DEFICIT-HYPERACTIVITY DISORDER ; REACTION-TIME-TASK ; DRINKING-WATER ; DEFICIT/HYPERACTIVITY DISORDER ; CHILDREN ; ADHD ; PERFORMANCE ; METHYLPHENIDATE ; DISINHIBITION ; ADOLESCENTS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24074 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif Santa Cruz, Dept Microbiol & Environm Toxicol, 1156 High St, Santa Cruz, CA 95064 USA; 2.Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA; 3.Cornell Univ, Dept Psychol, Ithaca, NY 14853 USA |
推荐引用方式 GB/T 7714 | Beaudin, Stephane A.,Strupp, Barbara J.,Strawderman, Myla,et al. Early Postnatal Manganese Exposure Causes Lasting Impairment of Selective and Focused Attention and Arousal Regulation in Adult Rats[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(2). |
APA | Beaudin, Stephane A.,Strupp, Barbara J.,Strawderman, Myla,&Smith, Donald R..(2017).Early Postnatal Manganese Exposure Causes Lasting Impairment of Selective and Focused Attention and Arousal Regulation in Adult Rats.ENVIRONMENTAL HEALTH PERSPECTIVES,125(2). |
MLA | Beaudin, Stephane A.,et al."Early Postnatal Manganese Exposure Causes Lasting Impairment of Selective and Focused Attention and Arousal Regulation in Adult Rats".ENVIRONMENTAL HEALTH PERSPECTIVES 125.2(2017). |
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