Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP508 |
Fetal Thyroid Function, Birth Weight, and in Utero Exposure to Fine Particle Air Pollution: A Birth Cohort Study | |
Janssen, Bram G.1; Saenen, Nelly D.1; Roels, Harry A.1,2; Madhloum, Narjes1; Gyselaers, Wilfried3,4; Lefebvre, Wouter5; Penders, Joris3,6; Vanpoucke, Charlotte7; Vrijens, Karen1; Nawrot, Tim S.1,8 | |
2017-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | Belgium |
英文摘要 | BACKGROUND: Thyroid hormones are critical for fetal development and growth. Whether prenatal exposure to fine particle air pollution (<= 2.5 mu m; PM2.5) affects fetal thyroid function and what the impact is on birth weight in normal healthy pregnancies have not been studied yet. Objectives: We studied the impact of third-trimester PM2.5 exposure on fetal and maternal thyroid hormones and their mediating role on birth weight. METHODS: We measured the levels of free thyroid hormones (FT3, FT4) and thyroid-stimulating hormone (TSH) in cord blood (n= 499) and maternal blood (n= 431) collected after delivery from mother-child pairs enrolled between February 2010 and June 2014 in the ENVIRONAGE birth cohort with catchment area in the province of Limburg, Belgium. RESULTS: An interquartile range (IQR) increment (8.2 mu g/m(3)) in third-trimester PM2.5 exposure was inversely associated with cord blood TSH levels (-11.6%; 95% CI: -21.8, -0.1) and the FT4/FT3 ratio (-62.7%; 95% CI: -91.6, -33.8). A 10th-90th percentile decrease in cord blood FT4 levels was associated with a 56g decrease in mean birth weight (95% CI: -90, -23). Assuming causality, we estimated that cord blood FT4 mediated 21% (-19 g; 95% CI: -37, -1) of the estimated effect of an IQR increment in third-trimester PM2.5 exposure on birth weight. Thirdtrimester PM2.5 exposure was inversely but not significantly associated with maternal blood FT4 levels collected 1day after delivery (-4.0%, 95% CI: -8.0, 0.2 for an IQR increment in -third-trimester PM2.5). CONCLUSIONS: In our study population of normal healthy pregnancies, third-trimester exposure to PM2.5 air pollution was associated with differences in fetal thyroid hormone levels that may contribute to reduced birth weight. Additional research is needed to confirm our findings in other populations and to evaluate potential consequences later in life. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397904400033 |
WOS关键词 | CORD-BLOOD ; STIMULATING HORMONE ; EARLY-PREGNANCY ; PARTICULATE MATTER ; HYPOTHYROIDISM ; THYROXINE ; GESTATION ; DELIVERY ; SMOKING |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24064 |
专题 | 资源环境科学 |
作者单位 | 1.Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium; 2.Catholic Univ Louvain, Louvain Ctr Toxicol & Appl Pharmacol LTAP, Brussels, Belgium; 3.Hasselt Univ, Biomed Res Inst, Hasselt, Belgium; 4.East Limburg Hosp, Dept Obstet, Genk, Belgium; 5.Flemish Inst Technol Res VITO, Mol, Belgium; 6.East Limburg Hosp, Dept Biol Clin, Genk, Belgium; 7.Belgian Interreg Environm Agcy, Brussels, Belgium; 8.Leuven Univ, Dept Publ Hlth & Primary Care Occupat & Environm, Leuven, Belgium |
推荐引用方式 GB/T 7714 | Janssen, Bram G.,Saenen, Nelly D.,Roels, Harry A.,et al. Fetal Thyroid Function, Birth Weight, and in Utero Exposure to Fine Particle Air Pollution: A Birth Cohort Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(4). |
APA | Janssen, Bram G..,Saenen, Nelly D..,Roels, Harry A..,Madhloum, Narjes.,Gyselaers, Wilfried.,...&Nawrot, Tim S..(2017).Fetal Thyroid Function, Birth Weight, and in Utero Exposure to Fine Particle Air Pollution: A Birth Cohort Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(4). |
MLA | Janssen, Bram G.,et al."Fetal Thyroid Function, Birth Weight, and in Utero Exposure to Fine Particle Air Pollution: A Birth Cohort Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.4(2017). |
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