Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1435 |
Has Toxicity Testing Moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology | |
Zaunbrecher, Virginia1,2; Beryt, Elizabeth3; Parodi, Daniela4; Telesca, Donatello5; Doherty, Joseph2; Malloy, Timothy1,2,6; Allard, Patrick1,4,6 | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Ten years ago, leaders in the field of toxicology called for a transformation of the discipline and a shift from primarily relying on traditional animal testing to incorporating advances in biotechnology and predictive methodologies into alternative testing strategies (ATS). Governmental agencies and academic and industry partners initiated programs to support such a transformation, but a decade later, the outcomes of these efforts are not well understood. OBJECTIVES: We aimed to assess the use of ATS and the perceived barriers and drivers to their adoption by toxicologists and by others working in, or closely linked with, the field of toxicology. METHODS: We surveyed 1,381 toxicologists and experts in associated fields regarding the viability and use of ATS and the perceived barriers and drivers of ATS for a range of applications. We performed ranking, hierarchical clustering, and correlation analyses of the survey data. RESULTS: Many respondents indicated that they were already using ATS, or believed that ATS were already viable approaches, for toxicological assessment of one or more end points in their primary area of interest or concern (26-86%, depending on the specific ATS/application pair). However, the proportions of respondents reporting use of ATS in the previous 12 mo were smaller (4.5-41%). Concern about regulatory acceptance was the most commonly cited factor inhibiting the adoption of ATS, and a variety of technical concerns were also cited as significant barriers to ATS viability. The factors most often cited as playing a significant role (currently or in the future) in driving the adoption of ATS were the need for expedited toxicology information, the need for reduced toxicity testing costs, demand by regulatory agencies, and ethical or moral concerns. CONCLUSIONS: Our findings indicate that the transformation of the field of toxicology is partly implemented, but significant barriers to acceptance and adoption remain. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000461491100004 |
WOS关键词 | RISK-ASSESSMENT ; DECISIONS ; CHEMICALS ; VISION |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24061 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif Los Angeles, Sustainable Technol & Policy Program, Los Angeles, CA 90095 USA; 2.Univ Calif Los Angeles, Sch Law, Los Angeles, CA 90095 USA; 3.Univ Calif Los Angeles, Luskin Sch Publ Affairs, Los Angeles, CA 90095 USA; 4.Univ Calif Los Angeles, Inst Soc & Genet, 3360 Life Sci Bldg, Los Angeles, CA 90095 USA; 5.Univ Calif Los Angeles, Dept Biostat, UCLA Fielding Sch Publ Hlth, Los Angeles, CA 90095 USA; 6.Univ Calif Los Angeles, Dept Environm Hlth Sci, UCLA Fielding Sch Publ Hlth, Los Angeles, CA 90095 USA |
推荐引用方式 GB/T 7714 | Zaunbrecher, Virginia,Beryt, Elizabeth,Parodi, Daniela,et al. Has Toxicity Testing Moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Zaunbrecher, Virginia.,Beryt, Elizabeth.,Parodi, Daniela.,Telesca, Donatello.,Doherty, Joseph.,...&Allard, Patrick.(2017).Has Toxicity Testing Moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Zaunbrecher, Virginia,et al."Has Toxicity Testing Moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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