Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP291 |
Neonatal Cord Blood Oxylipins and Exposure to Particulate Matter in the Early-Life Environment: An ENVIRONAGE Birth Cohort Study | |
Martens, Dries S.1; Gouveia, Sandra2; Madhloum, Narjes1; Janssen, Bram G.1; Plusquin, Michelle1,3; Vanpoucke, Charlotte4; Lefebvre, Wouter5; Forsberg, Bertil6; Nording, Malin2; Nawrot, Tim S.1,7 | |
2017-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | Belgium; Sweden; England |
英文摘要 | BACKGROUND: As part of the lipidome, oxylipins are bioactive lipid compounds originating from oxidation of different fatty acids. Oxylipins could provide a new target in the developmental origins model or the ability of early life exposure to change biology. OBJECTIVES: We studied the association between inutero PM2.5 (particulate matter with aerodynamic diameter < 2.5 mu m) exposure and oxylipin profiles in newborns. METHODS: Thirty-seven oxylipins reflecting the cyclooxygenase (COX), lipoxygenase (5-LOX and 12/15-LOX), and cytochrome P450 (CYP) pathways were assayed in 197 cord blood plasma samples from the ENVIRONAGE birth cohort. Principal component (PC) analysis and multiple regression models were used to estimate associations of inutero PM2.5 exposure with oxylipin pathways and individual metabolites. RESULTS: A principal component representing the 5-LOX pathway (6 metabolites) was significantly positively associated with PM2.5 exposure during the entire (multiple testing-adjusted q-value=0.05) and second trimester of pregnancy (q=0.05). A principal component representing the 12/15-LOX pathway (11 metabolites) was positively associated with PM2.5 exposure during the second trimester of pregnancy (q=0.05). PM2.5 was not significantly associated with the COX pathway during any time period. There was a positive but nonsignificant association between second-trimester PM2.5 and the CYP pathway (q=0.16). CONCLUSION: Inutero exposure to particulate matter, particularly during the second trimester, was associated with differences in the cord blood levels of metabolites derived from the lipoxygenase pathways. These differences may indicate an effect of air pollution during inutero life on the inflammatory state of the newborn at birth. Oxylipins may be important mediators between early life exposures and health outcomes later in life. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397904400032 |
WOS关键词 | AIR-POLLUTION ; MODEL CHAIN ; HEALTH ; DISEASE ; FETAL ; INFLAMMATION ; METABOLISM ; LIPIDOMICS ; PREGNANCY ; PROFILES |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23945 |
专题 | 资源环境科学 |
作者单位 | 1.Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium; 2.Umea Univ, Dept Chem, Umea, Sweden; 3.Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London, England; 4.Belgian Interreg Environm Agcy, Brussels, Belgium; 5.Flemish Inst Technol Res VITO, Mol, Belgium; 6.Umea Univ, Div Occupat & Environm Med, Umea, Sweden; 7.Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium |
推荐引用方式 GB/T 7714 | Martens, Dries S.,Gouveia, Sandra,Madhloum, Narjes,et al. Neonatal Cord Blood Oxylipins and Exposure to Particulate Matter in the Early-Life Environment: An ENVIRONAGE Birth Cohort Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(4). |
APA | Martens, Dries S..,Gouveia, Sandra.,Madhloum, Narjes.,Janssen, Bram G..,Plusquin, Michelle.,...&Nawrot, Tim S..(2017).Neonatal Cord Blood Oxylipins and Exposure to Particulate Matter in the Early-Life Environment: An ENVIRONAGE Birth Cohort Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(4). |
MLA | Martens, Dries S.,et al."Neonatal Cord Blood Oxylipins and Exposure to Particulate Matter in the Early-Life Environment: An ENVIRONAGE Birth Cohort Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.4(2017). |
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