GSTDTAP  > 资源环境科学
DOI10.1289/EHP2777
Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children
Jackson-Browne, Medina S.1; Papandonatos, George D.2; Chen, Aimin3; Calafat, Antonia M.4; Yolton, Kimberly5; Lanphear, Bruce P.6; Braun, Joseph M.1
2018-05-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2018
卷号126期号:5
文章类型Article
语种英语
国家USA; Canada
英文摘要

BACKGROUND: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment.


OBJECTIVE: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study.


METHODS: We quantified triclosan in urine samples from mother-child pairs up to nine times between the second trimester of gestation and 8 y of age. The Wechsler Intelligence Scale for Children-IV [i.e., Full-Scale Intelligence Quotient (IQ)] assessment was administered to HOME Study children at 8 y of age. We estimated covariate-adjusted triclosan-IQ associations at each visit. We also tested whether associations between triclosan concentrations and cognitive test scores varied among exposure at different time periods.


RESULTS: Full-Scale IQ was not significantly associated with urinary triclosan concentrations during gestation or childhood but was significantly associated with a 10-fold increase in maternal urinary triclosan concentration at delivery [-4.5 points (95% CI: -7.0, -2.0)]. Perceptual Reasoning Index (PRI) scores were significantly decreased in association with urinary triclosan concentrations at delivery and at 2 y of age. Associations between repeated triclosan concentrations and cognitive test scores significantly varied among exposure at different time periods for Full-Scale IQ, PRI, Verbal Comprehension Index, and Working Memory (triclosan-visit interaction p < 0.04).


CONCLUSION: Urinary triclosan concentrations at delivery, but not during mid to late pregnancy and childhood, were associated with significantly lower children's cognitive test scores at 8 y of age in this cohort of U.S. children.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000432619700006
WOS关键词BISPHENOL-A EXPOSURE ; MOUSE NEOCORTICAL NEURONS ; MATERNAL THYROID-FUNCTION ; URINARY CONCENTRATIONS ; UNITED-STATES ; CHILDHOOD ; VARIABILITY ; PREGNANCY ; PREDICTORS ; TOXICITY
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/23941
专题资源环境科学
作者单位1.Brown Univ, Dept Epidemiol, Providence, RI 02912 USA;
2.Brown Univ, Dept Biostat, Providence, RI 02912 USA;
3.Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Epidemiol, Cincinnati, OH 45267 USA;
4.Ctr Dis Control & Prevent CDC, Natl Ctr Environm Hlth, Atlanta, GA USA;
5.Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA;
6.Simon Fraser Univ, British Columbia Childrens Hosp, Fac Hlth Sci, Vancouver, BC, Canada
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GB/T 7714
Jackson-Browne, Medina S.,Papandonatos, George D.,Chen, Aimin,et al. Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(5).
APA Jackson-Browne, Medina S..,Papandonatos, George D..,Chen, Aimin.,Calafat, Antonia M..,Yolton, Kimberly.,...&Braun, Joseph M..(2018).Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children.ENVIRONMENTAL HEALTH PERSPECTIVES,126(5).
MLA Jackson-Browne, Medina S.,et al."Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children".ENVIRONMENTAL HEALTH PERSPECTIVES 126.5(2018).
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