Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2777 |
Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children | |
Jackson-Browne, Medina S.1; Papandonatos, George D.2; Chen, Aimin3; Calafat, Antonia M.4; Yolton, Kimberly5; Lanphear, Bruce P.6; Braun, Joseph M.1 | |
2018-05-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:5 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Canada |
英文摘要 | BACKGROUND: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment. OBJECTIVE: Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study. METHODS: We quantified triclosan in urine samples from mother-child pairs up to nine times between the second trimester of gestation and 8 y of age. The Wechsler Intelligence Scale for Children-IV [i.e., Full-Scale Intelligence Quotient (IQ)] assessment was administered to HOME Study children at 8 y of age. We estimated covariate-adjusted triclosan-IQ associations at each visit. We also tested whether associations between triclosan concentrations and cognitive test scores varied among exposure at different time periods. RESULTS: Full-Scale IQ was not significantly associated with urinary triclosan concentrations during gestation or childhood but was significantly associated with a 10-fold increase in maternal urinary triclosan concentration at delivery [-4.5 points (95% CI: -7.0, -2.0)]. Perceptual Reasoning Index (PRI) scores were significantly decreased in association with urinary triclosan concentrations at delivery and at 2 y of age. Associations between repeated triclosan concentrations and cognitive test scores significantly varied among exposure at different time periods for Full-Scale IQ, PRI, Verbal Comprehension Index, and Working Memory (triclosan-visit interaction p < 0.04). CONCLUSION: Urinary triclosan concentrations at delivery, but not during mid to late pregnancy and childhood, were associated with significantly lower children's cognitive test scores at 8 y of age in this cohort of U.S. children. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000432619700006 |
WOS关键词 | BISPHENOL-A EXPOSURE ; MOUSE NEOCORTICAL NEURONS ; MATERNAL THYROID-FUNCTION ; URINARY CONCENTRATIONS ; UNITED-STATES ; CHILDHOOD ; VARIABILITY ; PREGNANCY ; PREDICTORS ; TOXICITY |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23941 |
专题 | 资源环境科学 |
作者单位 | 1.Brown Univ, Dept Epidemiol, Providence, RI 02912 USA; 2.Brown Univ, Dept Biostat, Providence, RI 02912 USA; 3.Univ Cincinnati, Coll Med, Dept Environm Hlth, Div Epidemiol, Cincinnati, OH 45267 USA; 4.Ctr Dis Control & Prevent CDC, Natl Ctr Environm Hlth, Atlanta, GA USA; 5.Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA; 6.Simon Fraser Univ, British Columbia Childrens Hosp, Fac Hlth Sci, Vancouver, BC, Canada |
推荐引用方式 GB/T 7714 | Jackson-Browne, Medina S.,Papandonatos, George D.,Chen, Aimin,et al. Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(5). |
APA | Jackson-Browne, Medina S..,Papandonatos, George D..,Chen, Aimin.,Calafat, Antonia M..,Yolton, Kimberly.,...&Braun, Joseph M..(2018).Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children.ENVIRONMENTAL HEALTH PERSPECTIVES,126(5). |
MLA | Jackson-Browne, Medina S.,et al."Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children".ENVIRONMENTAL HEALTH PERSPECTIVES 126.5(2018). |
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