Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP577 |
The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence | |
Kuo, Chin-Chi1,2,3,4,5,6; Moon, Katherine A.1,2,3; Wang, Shu-Li7; Silbergeld, Ellen2; Navas-Acien, Ana1,2,3,8 | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Review |
语种 | 英语 |
国家 | USA; Taiwan |
英文摘要 | BACKGROUND: The available evidence on the role of arsenic metabolism in individual susceptibility to the development of cardiovascular disease, and diabetes has not been formally and comprehensively reviewed. OBJECTIVES: Our goal was to systematically investigate the association of arsenic metabolism with cancer, cardiovascular disease, and diabetes related outcomes in epidemiologic studies. As a secondary objective, we characterized the variation of arsenic metabolism in different populations worldwide. METHODS: We searched Medline/PubMed and EMBASE from inception to January 2016 and applied predetermined exclusion criteria. Compositional data analysis was used to describe the distribution of arsenic metabolism biomarkers and evaluate the association between arsenic exposure and metabolism. RESULTS: Twenty-eight studies met the inclusion criteria, 12 on cancer, nine on cardiovascular disease, and seven on diabetes-related outcomes. The median (interquartile range) for mean iAs%, MMA%, and DMA% was 11.2 (7.8-14.9)%, 13.0 (10.4-13.6)%, and 74.9 (69.8-80.0)%, respectively. Findings across studies suggested that higher arsenic exposure levels were associated with higher iAs% and lower DMA% and not associated with MMA%. For cancer, most studies found a pattern of higher MMA% and lower DMA% associated with higher risk of all -site, urothelial, lung, and skin cancers. For cardiovascular disease, higher MMA`,1i, was generally associated with higher risk of carotid atherosclerosis and clinical cardiovascular disease but not with hypertension. For diabetes-related outcomes, the pattern of lower MMA% and higher DMA% was associated with higher risk of metabolic syndrome and diabetes. CONCLUSIONS: Population level of iAs% and DMA%, but not MMA%, were associated with arsenic exposure levels. Overall, study findings suggest that higher MM A% was associated with an increased risk of cancer and cardiovascular disease, while lower MMA% was associated with an increased risk of diabetes and metabolic syndrome. Additional population-based studies and experimental studies are needed to further evaluate and understand the role of arsenic exposure in arsenic metabolism and the role of arsenic metabolism in disease development. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413790600011 |
WOS关键词 | ENVIRONMENTAL TOBACCO-SMOKE ; UROTHELIAL CARCINOMA RISK ; INTIMA-MEDIA THICKNESS ; ONE-CARBON METABOLISM ; BASAL-CELL CARCINOMA ; METHYLATION CAPACITY ; DRINKING-WATER ; BLADDER-CANCER ; ENDEMIC AREA ; HYPERENDEMIC AREAS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23831 |
专题 | 资源环境科学 |
作者单位 | 1.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA; 2.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA; 3.Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA; 4.China Med Univ, Kidney Inst, 2 Yude Rd, Taichung 404, Taiwan; 5.China Med Univ, Big Data Ctr, China Med Univ Hosp, 2 Yude Rd, Taichung 404, Taiwan; 6.China Med Univ, Coll Med, 2 Yude Rd, Taichung 404, Taiwan; 7.Natl Hlth Res Inst, Natl Inst Environm Hlth Sci, Miaoli, Taiwan; 8.Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA |
推荐引用方式 GB/T 7714 | Kuo, Chin-Chi,Moon, Katherine A.,Wang, Shu-Li,et al. The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Kuo, Chin-Chi,Moon, Katherine A.,Wang, Shu-Li,Silbergeld, Ellen,&Navas-Acien, Ana.(2017).The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Kuo, Chin-Chi,et al."The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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