Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1178 |
Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis | |
Johns, Lauren E.1; Ferguson, Kelly K.1,2; Cantonwine, David E.3; McElrath, Thomas F.3; Mukhedee, Bhramar4; Meeker, John D.1 | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: In addition to its well-established role in maintaining skeletal health, vitamin D has essential regulatory functions in female reproductive and pregnancy outcomes. Phthalates and bisphenol A (BPA) are endocrine disruptors, and previous research has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults. OBJECTIVES: We investigated the relationships between repeated measures of urinary phthalate metabolites and BPA and circulating total 25(OH)D in a prospective cohort of pregnant women. METHODS: The present study population includes participants (n = 477) in a nested case control study of preterm birth drawn from a prospective birth cohort of pregnant women at Brigham and Women's Hospital in Boston, Massachusetts. Urine and blood samples were collected for biomarker measurements at median 10 wk and 26 wk of gestation. RESULTS: in repeated measures analysis, we observed that an interquartile range (IQR) increase in urinary mono-3-carboxypropyl phthalate (MCPP) was associated with a 4.48% decrease [95% confidence interval (CI): -7.37, -1.58] in total 25(OH)D. We also detected inverse associations for metabolites of di(2-ethylhexyl) phthalate (DEHP) [percent difference (%Delta) = -2.83 to -2.16]. For BPA, we observed a nonsignificant inverse association with total 25(OH)D in the overall population. Our sensitivity analysis revealed that the associations for some metabolites (e.g., MEHP) varied by race/ethnicity, which may reflect potential differences in susceptibility. In agreement with findings from repeated measures analysis, we reported that DEHP metabolites and BPA were significantly associated with an approximate 20% increase in the odds of vitamin D deficiency (<= 20 ng/mL) [odds ratio (95% CI): 1.19 (1.06, 1.35) for molar sum of DEHP metabolites and 1.22 (1.01, 1.47) for BPA] at median 10 wk and 26 wk, respectively. CONCLUSIONS: Our results provide suggestive evidence of the potential for environmental exposure to phthalates and/or BPA to disrupt circulating vitamin D levels in pregnancy. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000461491100006 |
WOS关键词 | BISPHENOL-A ; 25-HYDROXYVITAMIN D ; D DEFICIENCY ; THYROID-HORMONES ; D-RECEPTOR ; EXPOSURE ; EXPRESSION ; HEALTH ; PHENOLS ; RISK |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23828 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1835 SPH I,1415 Washington Hts, Ann Arbor, MI 48109 USA; 2.NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA; 3.Harvard Med Sch, Brigham & Womens Hosp, Div Maternal Fetal Med, Boston, MA 02115 USA; 4.Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA |
推荐引用方式 GB/T 7714 | Johns, Lauren E.,Ferguson, Kelly K.,Cantonwine, David E.,et al. Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Johns, Lauren E.,Ferguson, Kelly K.,Cantonwine, David E.,McElrath, Thomas F.,Mukhedee, Bhramar,&Meeker, John D..(2017).Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Johns, Lauren E.,et al."Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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