Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP826 |
A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants | |
Martin, Olwenn V.1; Evans, Richard M.1; Faust, Michael2; Kortenkamp, Andreas1 | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Germany |
英文摘要 | BACKGROUND: The European Food Safety Authority recently concluded that the exposure of small children (1-3 y old) to brominated diphenyl ether (BDE)-99 may exceed acceptable levels defined in relation to neurodevelopmental toxicity in rodents. The flame retardant BDE-209 may release BDE-99 and other lower brominated BDEs through biotic and abiotic degradation, and all age groups are exposed not only to BDE-209 and -99 but also to a cocktail of BILE congeners with evidence of neurodevelopmental toxicity. The possible risks from combined exposures to these substances have not been evaluated. OBJECTIVES: We performed a congener-specific mixture risk assessment (MRA) of human exposure to combinations of BDE-209 and other BDEs based on estimated exposures via diet and dust intake and on measured levels in biologic samples. METHODS: We employed the Hazard Index (HI) method by using BDE congener-specific reference doses for neurodevelopmental toxicity. RESULTS: Our HI analysis suggests that combined exposures to polybrominated diphenyl ethers (PBDEs) may exceed acceptable levels in breastfeeding infants (0-3 mo old) and in small children (1-3 y old), even for moderate (vs. high) exposure scenarios. Our estimates also suggest that acceptable levels of combined PBDEs may he exceeded in adults whose diets are high in fish. Small children had the highest combined exposures, with some estimated body burdens that were similar to body burdens associated with developmental neurotoxicity in rodents. CONCLUSIONS: Our estimates corroborate reports from several recent epidemiological studies of associations between PBDE exposures and neurobehavioral outcomes, and they support the inclusion of BDE-209 in the persistent organic pollutant (POP) convention as well as the need for strategies to reduce exposures to PBDE mixtures, including maximum residue limits for PBDEs in food and measures for limiting the release of PBDEs from consumer waste. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413790600026 |
WOS关键词 | EXPOSURE ASSESSMENT ; BREAST-MILK ; SPONTANEOUS BEHAVIOR ; NEONATAL EXPOSURE ; HUMAN FETUSES ; CORD SERUM ; BODY-FAT ; CHILDREN ; MICE ; PBDE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23565 |
专题 | 资源环境科学 |
作者单位 | 1.Brunel Univ London, Inst Environm Hlth & Soc, London, England; 2.Faust & Backhaus, BITZ Bremer Innovat & Technol Zentrum, Bremen, Germany |
推荐引用方式 GB/T 7714 | Martin, Olwenn V.,Evans, Richard M.,Faust, Michael,et al. A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Martin, Olwenn V.,Evans, Richard M.,Faust, Michael,&Kortenkamp, Andreas.(2017).A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Martin, Olwenn V.,et al."A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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