Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP505 |
Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring | |
Lejonklou, Margareta H.1; Dunder, Linda1; Bladin, Emelie1; Pettersson, Vendela1; Ronn, Monika1; Lind, Lars3; Walden, Tomas B.2; Lind, P. Monica1 | |
2017-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden |
英文摘要 | BACKGROUND: Bisphenol A (BPA) is an endocrine-disrupting chemical that may contribute to development of obesity and metabolic disorders. Humans are constantly exposed to low concentrations of BPA, and studies support that the developmental period is particularly sensitive. OBJECTIVES: The aim was to investigate the effects of low-dose developmental BPA exposure on metabolic parameters in male and female Fischer 344 (F344) rat offspring. METHODS: Pregnant F344 rats were exposed to BPA via their drinking water, corresponding to 0.5 mu g/kg BW/d (BPA0.5; n=21) or 50 mu g/kg BW/d (BPA50; n=16), from gestational day (GD) 3.5 until postnatal day (PND) 22, and controls were given vehicle (n=26). Body weight (BW), adipose tissue, liver (weight, histology, and gene expression), heart weight, and lipid profile were investigated in the 5-wk-old offspring. RESULTS: Males and females exhibited differential susceptibility to the different doses of BPA. Developmental BPA exposure increased plasma triglyceride levels (0.81 +/- 0.10mmol/L compared with 0.57 +/- 0.03mmol/L, females BPA50 p=0.04; 0.81 +/- 0.05mmol/L compared with 0.61 +/- 0.04mmol/L, males BPA0.5 p=0.005) in F344 rat offspring compared with controls. BPA exposure also increased adipocyte cell density by 122% in inguinal white adipose tissue (iWAT) of female offspring exposed to BPA0.5 compared with controls (68.2 +/- 4.4 number of adipocytes/HPF compared with 55.9 +/- 1.5 number of adipocytes/HPF; p=0.03) and by 123% in BPA0.5 females compared with BPA50 animals (68.2 +/- 4.4 number of adipocytes/high power field (HPF) compared with 55.3 +/- 2.9 number of adipocytes/HPF; p=0.04). In iWAT of male offspring, adipocyte cell density was increased by 129% in BPA50-exposed animals compared with BPA0.5-exposed animals (69.9 +/- 5.1 number of adipocytes/HPF compared with 54.0 +/- 3.4 number of adipocytes/HPF; p=0.03). Furthermore, the expression of genes involved in lipid and adipocyte homeostasis was significantly different between exposed animals and controls depending on the tissue, dose, and sex. CONCLUSIONS: Developmental exposure to 0.5 mu g/kg BW/d of BPA, which is 810 times lower than the current preliminary EFSA (European Food Safety Authority) tolerable daily intake (TDI) of 4 mu g/kg BW/d and is within the range of environmentally relevant levels, was associated with sex-specific differences in the expression of genes in adipose tissue plasma triglyceride levels in males and adipocyte cell density in females when F344 rat offspring of dams exposed to BPA at 0.5 mu g/kg BW/d were compared with the offspring of unexposed controls. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413788400027 |
WOS关键词 | PERINATAL EXPOSURE ; BPA EXPOSURE ; REPRODUCTIVE TOXICITY ; ENDOCRINE DISRUPTORS ; NEONATAL EXPOSURE ; FOOD-INTAKE ; IN-VITRO ; MOUSE ; FAT ; ADIPONECTIN |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23499 |
专题 | 资源环境科学 |
作者单位 | 1.Uppsala Univ, Dept Med Sci Occupat & Environm Med, Uppsala, Sweden; 2.Uppsala Univ, Dept Med Cell Biol, Uppsala, Sweden; 3.Uppsala Univ, Dept Med Sci, Cardiovasc Epidemiol, Uppsala, Sweden |
推荐引用方式 GB/T 7714 | Lejonklou, Margareta H.,Dunder, Linda,Bladin, Emelie,et al. Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(6). |
APA | Lejonklou, Margareta H..,Dunder, Linda.,Bladin, Emelie.,Pettersson, Vendela.,Ronn, Monika.,...&Lind, P. Monica.(2017).Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring.ENVIRONMENTAL HEALTH PERSPECTIVES,125(6). |
MLA | Lejonklou, Margareta H.,et al."Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring".ENVIRONMENTAL HEALTH PERSPECTIVES 125.6(2017). |
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