Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1867 |
Air Toxics in Relation to Autism Diagnosis, Phenotype, and Severity in a US Family-Based Study | |
Kalkbrenner, Amy E.1; Windham, Gayle C.2; Zheng, Cheng1; McConnell, Rob3; Lee, Nora L.4; Schauer, James J.5; Thayer, Brian1; Pandey, Juhi6,7; Volk, Heather E.8 | |
2018-03-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:3 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Previous studies have reported associations of perinatal exposure to air toxics, including some metals and volatile organic compounds, with autism spectrum disorder (ASD). OBJECTIVES: Our goal was to further explore associations of perinatal air toxics with ASD and associated quantitative traits in high-risk multiplex families. METHODS: We included participants of a U.S. family-based study [the Autism Genetic Resource Exchange (AGRE)] who were born between 1994 and 2007 and had address information. We assessed associations between average annual concentrations at birth for each of 155 air toxics from the U.S. EPA emissions-based National-scale Air Toxics Assessment and a) ASD diagnosis (1,540 cases and 477 controls); b) a continuous measure of autism-related traits, the Social Responsiveness Scale (SRS, among 1,272 cases and controls); and c) a measure of autism severity, the Calibrated Severity Score (among 1,380 cases). In addition to the individual's air toxic level, mixed models (clustering on family) included the family mean air toxic level, birth year, and census covariates, with consideration of the false discovery rate. RESULTS: ASD diagnosis was positively associated with propionaldehyde, methyl tert-butyl ether (MTBE), bromoform, 1,4-dioxane, dibenzofurans, and glycol ethers and was inversely associated with 1,4-dichlorobenzene, 4,4'-methylene diphenyl diisocyanate (MDI), benzidine, and ethyl carbamate (urethane). These associations were robust to adjustment in two-pollutant models. Autism severity was associated positively with carbon disulfide and chlorobenzene, and negatively with 1,4-dichlorobenzene. There were no associations with the SRS. CONCLUSIONS: Some air toxics were associated with ASD risk and severity, including some traffic-related air pollutants and newly-reported associations, but other previously reported associations with metals and volatile organic compounds were not reproducible. |
领域 | 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000428419000001 |
WOS关键词 | GENETIC RESOURCE EXCHANGE ; SPECTRUM DISORDERS ; CHEMICAL-MIXTURES ; RISK ; POLLUTION ; POLLUTANTS ; EXPOSURES ; HEALTH ; EPIDEMIOLOGY ; INTERVIEW |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23326 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Wisconsin, Joseph J Zilber Sch Pub Hlth, Milwaukee, WI 53201 USA; 2.Calif Dept Publ Hlth, Div Environm & Occupat Dis Control, Richmond, CA USA; 3.Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA USA; 4.Drexel Univ, Dornsife Sch Publ Hlth, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA; 5.Univ Wisconsin, Dept Civil & Environm Engn, Madison, WI 53706 USA; 6.Childrens Hosp Philadelphia, Ctr Autism Res, Philadelphia, PA 19104 USA; 7.Univ Penn, Philadelphia, PA 19104 USA; 8.Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA |
推荐引用方式 GB/T 7714 | Kalkbrenner, Amy E.,Windham, Gayle C.,Zheng, Cheng,et al. Air Toxics in Relation to Autism Diagnosis, Phenotype, and Severity in a US Family-Based Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(3). |
APA | Kalkbrenner, Amy E..,Windham, Gayle C..,Zheng, Cheng.,McConnell, Rob.,Lee, Nora L..,...&Volk, Heather E..(2018).Air Toxics in Relation to Autism Diagnosis, Phenotype, and Severity in a US Family-Based Study.ENVIRONMENTAL HEALTH PERSPECTIVES,126(3). |
MLA | Kalkbrenner, Amy E.,et al."Air Toxics in Relation to Autism Diagnosis, Phenotype, and Severity in a US Family-Based Study".ENVIRONMENTAL HEALTH PERSPECTIVES 126.3(2018). |
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