Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1203 |
Plasma Perfluoroalkyl and Polyfluoroalkyl Substances Concentration and Menstrual Cycle Characteristics in Preconception Women | |
Zhou, Wei1; Zhang, Lulu2,3; Tong, Chuanliang4; Fang, Fang1; Zhao, Shasha1; Tian, Ying1; Tao, Yexuan2,3; Zhang, Jun1 | |
2017-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
英文摘要 | BACKGROUND: Periluoroalkyl and polylluoroalkyl substances (PFASs) are persistent synthetic chemicals that are widely used in industrial applications and often detectable in humans. In rats, PFASs can interfere with the estrous cycle. In humans, menstruation has been viewed as a proxy of female fecundity, and periodic menstruation plays a critical role in endometrial sloughing in the absence of pregnancy and in preparing for embryo implantation. OBJECTIVES: We investigated the association between PEAS exposure and menstrual cycle characteristics in women who plan to become pregnant. METHODS: Plasma level of 10 PFASs was measured in 950 women who were attempting to become pregnant and recruited in two preconception care clinics in Shanghai, China, from August 2013 to April 2015. Information on menstrual cycle characteristics was collected by questionnaires. Associations between PFAS levels and menstrual cycle regularity, length, and bleeding volume were examined using multiple logistic regression models. RESULTS: Pre-pregnant women with higher levels of log-transformed perfluorooctanate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PENA), and perfluorohcxanesulfonate (PFHxS) had increased odds of self-reported history of irregular menstrual cycle [PFOA-adjusted odds ratio (OR] = 1.52 (95% CI: 1.08, 2.15); PPOS OR = 1.29 (95% CI: 0.98, 1.70); PENA OR = 1.50 (95% CI: 1.03, 2.07); PFHxS OR = 1.80 (95% CI: 1.17, 2.77)] and long menstrual cycle [PFOA OR = 1.50 (95% CI: 1.06, 2.10); PFOS OR = 1.34 (95% CI: 1.02, 1.75); PENA OR = 1.49 (95% CI: 1.05, 2.11); PFHxS OR = 1.73 (95% CI: 1.13, 2.65)]. Log-transformed PFOA, PFOS, PFNA. and PFHxS levels were negatively associated with self-reported history of menorrhagia [PFOA OR = 0.37 (95% CI: 0.21, 0.65); PFOS OR = 0.57 (95% CI: 0.37, 0.90); PFNA OR = 0.47 (95% CI: 0.26, 0.86); PFHxS OR = 0.14 (95% CI: 0.06, 0.36)]. CONCLUSIONS: Certain PEASs arc associated with abnormal menstruation in humans. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413788400021 |
WOS关键词 | LEYDIG-CELL FUNCTION ; PERFLUOROOCTANE SULFONATE ; PERFLUORINATED CHEMICALS ; IN-VITRO ; PREGNANCY ; EXPOSURE ; TIME ; ASSOCIATION ; LENGTH ; COHORT |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23258 |
专题 | 资源环境科学 |
作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Minist Educ,Shanghai Key Lab Childrens Environm H, Shanghai, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Clin Nutr, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai Key Lab Children Gastroenterol & Nutr, Shanghai, Peoples R China; 4.Int Peace Matern & Child Hlth Hosp, Dept Sci & Res, China Welf Inst, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Wei,Zhang, Lulu,Tong, Chuanliang,et al. Plasma Perfluoroalkyl and Polyfluoroalkyl Substances Concentration and Menstrual Cycle Characteristics in Preconception Women[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(6). |
APA | Zhou, Wei.,Zhang, Lulu.,Tong, Chuanliang.,Fang, Fang.,Zhao, Shasha.,...&Zhang, Jun.(2017).Plasma Perfluoroalkyl and Polyfluoroalkyl Substances Concentration and Menstrual Cycle Characteristics in Preconception Women.ENVIRONMENTAL HEALTH PERSPECTIVES,125(6). |
MLA | Zhou, Wei,et al."Plasma Perfluoroalkyl and Polyfluoroalkyl Substances Concentration and Menstrual Cycle Characteristics in Preconception Women".ENVIRONMENTAL HEALTH PERSPECTIVES 125.6(2017). |
条目包含的文件 | 条目无相关文件。 |
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