Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1759 |
An Integrated Chemical Environment to Support 21st-Century Toxicology | |
Bell, Shannon M.1; Phillips, Jason2; Sedykh, Alexander2; Tandon, Arpit2; Sprankle, Catherine1; Morefield, Stephen Q.1; Shapiro, Andy3; Allen, David1; Shah, Ruchir2; Maull, Elizabeth A.4; Casey, Warren M.4; Kleinstreuer, Nicole C.4 | |
2017-05-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:5 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Access to high-quality reference data is essential for the development, validation, and implementation of in vitro and in silico approaches that reduce and replace the use of animals in toxicity testing. Currently, these data must often be pooled from a variety of disparate sources to efficiently link a set of assay responses and model predictions to an outcome or hazard classification. To provide a central access point for these purposes, the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods developed the Integrated Chemical Environment (ICE) web resource. The ICE data integrator allows users to retrieve and combine data sets and to develop hypotheses through data exploration. Open-source computational workflows and models will be available for download and application to local data. ICE currently includes curated in vivo test data, reference chemical information, in vitro assay data (including Tox21 (TM)/ToxCast (TM) high-throughput screening data), and in silico model predictions. Users can query these data collections focusing on end points of interest such as acute systemic toxicity, endocrine disruption, skin sensitization, and many others. ICE is publicly accessible at https://ice.ntp.niehs.nih.gov. https://doi.org/10.1289/EHP1759. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413786500001 |
WOS关键词 | THROUGHPUT SCREENING DATA ; ACTOR |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23220 |
专题 | 资源环境科学 |
作者单位 | 1.Integrated Lab Syst Inc ILS, Res Triangle Pk, NC USA; 2.Sciome, Res Triangle Pk, NC USA; 3.NIEHS, Program Operat Branch, DHHS, NTP,NIH, POB 12233, Res Triangle Pk, NC 27709 USA; 4.NIEHS, DHHS, NTP Interagency Ctr Evaluat Alternat Toxicol Meth, NTP,NIH, POB 12233, Res Triangle Pk, NC 27709 USA |
推荐引用方式 GB/T 7714 | Bell, Shannon M.,Phillips, Jason,Sedykh, Alexander,et al. An Integrated Chemical Environment to Support 21st-Century Toxicology[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(5). |
APA | Bell, Shannon M..,Phillips, Jason.,Sedykh, Alexander.,Tandon, Arpit.,Sprankle, Catherine.,...&Kleinstreuer, Nicole C..(2017).An Integrated Chemical Environment to Support 21st-Century Toxicology.ENVIRONMENTAL HEALTH PERSPECTIVES,125(5). |
MLA | Bell, Shannon M.,et al."An Integrated Chemical Environment to Support 21st-Century Toxicology".ENVIRONMENTAL HEALTH PERSPECTIVES 125.5(2017). |
条目包含的文件 | 条目无相关文件。 |
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