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DOI | 10.1289/EHP1329 |
Influence of Tetrabromobisphenol A, with or without Concurrent Triclosan, upon Bisphenol A and Estradiol Concentrations in Mice | |
Pollock, Tyler; Mantella, Leanna; Reali, Vanessa; deCatanzaro, Denys | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada |
英文摘要 | BACKGROUND: Humans are commonly exposed to multiple environmental chemicals, including tetrabromobisphenol A (TBBPA; a flame retardant), triclosan (an antimicrobial agent), and bisphenol A (BPA; polycarbonate plastics). These chemicals are readily absorbed and may interact with each other. OBJECTIVES: We sought to determine whether TBBPA, given alone or in combination with triclosan, can modulate the concentrations of BPA and 17 beta-estradiol (E2). METHODS: Female and male CF-1 mice were each given a subcutaneous injection of 0-27 mg TBBPA, with or without concurrent 0.33 mg triclosan, followed by dietary administration of 50 mu g/kg body weight C-14-BPA. Radioactivity was measured in blood serum and tissues through liquid scintillation counting. In subsequent experiments, female and male CF-1 mice were each given a subcutaneous injection of 0 or 1 mg TBBPA and E2 was measured in urine 2-12 h after injection. RESULTS: Doses as low as 1 mg TBBPA significantly elevated 14C-BPA concentrations in the uterus and ovaries of females; in the testes, epididymides, vesicular-coagulating glands, and preputial glands of males; and in blood serum, heart, lungs, and kidneys of both sexes; urinary E2 concentrations were also elevated. Lower doses of TBBPA or triclosan that had no effects on their own elevated 14C-BPA concentrations when the two substances were given concurrently. CONCLUSION: These data indicate that TBBPA, triclosan, and BPA interact in vivo, consistent with evidence that TBBPA and triclosan inhibit enzymes that are critical for BPA and E2 metabolism. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413790600024 |
WOS关键词 | BROMINATED FLAME RETARDANTS ; WISTAR HAN RATS ; IN-VITRO ; ESTROGEN SULFOTRANSFERASE ; BLASTOCYST IMPLANTATION ; ER-ALPHA ; INTRAUTERINE IMPLANTATION ; TISSUE DISTRIBUTION ; ENZYME-IMMUNOASSAY ; POTENT INHIBITION |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23172 |
专题 | 资源环境科学 |
作者单位 | McMaster Univ, Dept Psychol Neurosci & Behav, 1280 Main St West, Hamilton, ON L8S 4K1, Canada |
推荐引用方式 GB/T 7714 | Pollock, Tyler,Mantella, Leanna,Reali, Vanessa,et al. Influence of Tetrabromobisphenol A, with or without Concurrent Triclosan, upon Bisphenol A and Estradiol Concentrations in Mice[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Pollock, Tyler,Mantella, Leanna,Reali, Vanessa,&deCatanzaro, Denys.(2017).Influence of Tetrabromobisphenol A, with or without Concurrent Triclosan, upon Bisphenol A and Estradiol Concentrations in Mice.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Pollock, Tyler,et al."Influence of Tetrabromobisphenol A, with or without Concurrent Triclosan, upon Bisphenol A and Estradiol Concentrations in Mice".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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