Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP3189 |
Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice | |
Tucker, Deirdre K.1,2; Bouknight, Schantel Hayes3; Brar, Sukhdev S.4; Kissling, Grace E.5; Fenton, Suzanne E.2 | |
2018-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Continued efforts to phase out bisphenol A (BPA) from consumer products have been met with the challenges of finding safer alternatives. OBJECTIVES: This study aimed to determine whether early-life exposure to BPA and its related analogues, bisphenol AF (BPAF) and bisphenol S (BPS), could affect female pubertal mammary gland development and long-term mammary health in mice. METHODS: Timed pregnant CD-1 mice were exposed to vehicle, BPA (0.5, 5, 50 mg/kg), BPAF (0.05, 0.5, 5 mg/kg), or BPS (0.05, 0.5, 5 mg/kg) via oral gavage between gestation days 10-17. Mammary glands were collected from resulting female offspring at postnatal day (PND) 20, 28, 35, and 56, and at 3, 8, and 14 months for whole mount, histopathological evaluation, and quantitative real-time polymerase chain reaction (qPCR), serum steroid concentrations were also measured at these time points. RESULTS: In the bisphenol-exposed mice, accelerated mammary gland development was evident during early puberty and persisted into adulthood. By late adulthood, mammary glands from bisphenol-exposed female offspring exhibited adverse morphology in comparison with controls; most prominent were undifferentiated duct ends, significantly more lobuloalveolar hyperplasia and perivascular inflammation, and various tumors, including adenocarcinomas. Effects were especially prominent in the BPAF 5 mg/kg and BPS 0.5 mg/kg groups. Serum steroid concentrations and mammary mRNA levels of Esrl, Pgr, Ar, and Gperl were similar to controls. CONCLUSIONS: These data demonstrate that prenatal exposure of mice to BPAF or BPS induced precocious development of the mammary gland, and that siblings were significantly more susceptible to spontaneous preneoplastic epithelial lesions and inflammation, with an incidence greater than that observed in vehicle - and BPA-exposed animals. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000444417500004 |
WOS关键词 | IN-UTERO EXPOSURE ; BREAST-CANCER ; PERINATAL EXPOSURE ; UNITED-STATES ; MANUFACTURING PLANT ; SPONTANEOUS TUMORS ; NEONATAL EXPOSURE ; ANDROGEN RECEPTOR ; MOUSE MAMMARY ; CD-1 MICE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23154 |
专题 | 资源环境科学 |
作者单位 | 1.Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27515 USA; 2.NIEHS, DNTP, NTP Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA; 3.Charles River Labs Inc, Durham, NC USA; 4.NIEHS, DNTP, Cellular & Mol Pathol Branch, POB 12233, Res Triangle Pk, NC 27709 USA; 5.NIEHS, Div Intramural Res, Biostat & Computat Biol Branch, POB 12233, Res Triangle Pk, NC 27709 USA |
推荐引用方式 GB/T 7714 | Tucker, Deirdre K.,Bouknight, Schantel Hayes,Brar, Sukhdev S.,et al. Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(8). |
APA | Tucker, Deirdre K.,Bouknight, Schantel Hayes,Brar, Sukhdev S.,Kissling, Grace E.,&Fenton, Suzanne E..(2018).Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice.ENVIRONMENTAL HEALTH PERSPECTIVES,126(8). |
MLA | Tucker, Deirdre K.,et al."Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice".ENVIRONMENTAL HEALTH PERSPECTIVES 126.8(2018). |
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