Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2662 |
Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure | |
Balik-Meisner, Michele1; Truong, Lisa2; Scholl, Elizabeth H.1; La Du, Jane K.2; Tanguay, Robert L.2; Reif, David M.1 | |
2018-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Modern societies are exposed to vast numbers of potentially hazardous chemicals. Despite demonstrated linkages between chemical exposure and severe health effects, there are limited, often conflicting, data on how adverse health effects of exposure differ across individuals. OBJECTIVES: We tested the hypothesis that population variability in response to certain chemicals could elucidate a role for gene environment interactions (GxE) in differential susceptibility. METHODS: High-throughput screening (HTS) data on thousands of chemicals in genetically heterogeneous zebrafish were leveraged to identify a candidate chemical (Abamectin) with response patterns indicative of population susceptibility differences. We tested the prediction by generating genome-wide sequence data for 276 individual zebrafish displaying susceptible (Affected) vs. resistant (Unaffected) phenotypes following identical chemical exposure. RESULTS: We found GxE associated with differential susceptibility in the sox7 promoter region and then confirmed gene expression differences between phenotypic response classes. CONCLUSIONS: The results for Abamectin in zebrafish demonstrate that GxE associated with naturally occurring, population genetic variation play a significant role in mediating individual response to chemical exposure. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000438820100005 |
WOS关键词 | IN-VITRO ; END-POINTS ; ZEBRAFISH ; GENOME ; TOXICITY ; DIVERSITY ; SEQUENCE ; IVERMECTIN ; FRAMEWORK ; LINKAGE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22960 |
专题 | 资源环境科学 |
作者单位 | 1.North Carolina State Univ, Ctr Human Hlth & Environm, Bioinformat Res Ctr, Dept Biol Sci, Raleigh, NC USA; 2.Oregon State Univ, Dept Environm & Mol Toxicol, Sinnhuber Aquatic Res Lab, Corvallis, OR 97331 USA |
推荐引用方式 GB/T 7714 | Balik-Meisner, Michele,Truong, Lisa,Scholl, Elizabeth H.,et al. Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(6). |
APA | Balik-Meisner, Michele,Truong, Lisa,Scholl, Elizabeth H.,La Du, Jane K.,Tanguay, Robert L.,&Reif, David M..(2018).Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure.ENVIRONMENTAL HEALTH PERSPECTIVES,126(6). |
MLA | Balik-Meisner, Michele,et al."Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure".ENVIRONMENTAL HEALTH PERSPECTIVES 126.6(2018). |
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