Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP256 |
Placental Pathology Associated with Household Air Pollution in a Cohort of Pregnant Women from Dar es Salaam, Tanzania | |
Wylie, Blair J.1,2,3; Matechi, Emmanuel4; Kishashu, Yahya5; Fawzi, Wafaie6; Premji, Zul5; Coull, Brent A.2,7; Hauser, Russ1,2,3,8; Ezzati, Majid9; Roberts, Drucilla J.3,10 | |
2017 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:1 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Tanzania; England |
英文摘要 | BACKGROUND: Smoke from the burning of biomass fuels has been linked with adverse pregnancy outcomes such as low birth weight, stillbirth, and prematurity. OBJECTIVE: To identify potential underlying mechanisms of adverse perinatal outcomes, we explored the association of placental pathology with household air pollution in pregnant women from urban/periurban Tanzania who cook predominantly with charcoal. METHODS: Between 2011 and 2013, we measured personal exposures to fine particulate matter (PM2.5) and carbon monoxide (CO) over 72 hr among a cohort of Tanzanian pregnant women. Placentas were collected after delivery for examination. Placental pathologies of inflammatory, hypoxic, ischemic/hypertensive, infectious and thrombotic etiologies were diagnosed, blinded to exposure levels. Using multiple logistic regression, we explored the association of PM2.5 and CO exposure with placental pathology. RESULTS: One hundred sixteen women had personal air exposure measurements and placental histopathology available for analysis. PM2.5 and CO exposures were moderate [geometric means (GSD) were 40.5 mu g/m(3) (17.3) and 2.21 ppm (1.47) respectively]; 88.6% of PM2.5 measurements exceeded World Health Organization air quality guidelines. We observed an increase in the odds (per 1-unit increase in exposure on the ln-scale) of fetal thrombotic vasculopathy (FTV) both with increasing PM2.5 [adjusted odds ratio (aOR) = 5.5; 95% CI: 1.1, 26.8] and CO measurements (aOR = 2.5; 95% CI: 1.0, 6.4) in adjusted models only. FTV also was more common among pregnancies complicated by stillbirth or low birth weight. CONCLUSIONS: Fetal thrombosis may contribute to the adverse outcomes associated with household air pollution from cook stoves during pregnancy. Larger studies are necessary for confirmation. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000392195000018 |
WOS关键词 | FETAL THROMBOTIC VASCULOPATHY ; PARTICULATE MATTER ; REACTION PATTERNS ; CARBON-MONOXIDE ; BIOMASS FUELS ; REPRODUCIBILITY ; CHORANGIOSIS ; PARTICLES ; NOSOLOGY ; CHILDREN |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22731 |
专题 | 资源环境科学 |
作者单位 | 1.Massachusetts Gen Hosp, Dept Obstet Gynecol, Boston, MA 02114 USA; 2.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 3.Harvard Med Sch, Boston, MA USA; 4.African Acad Publ Hlth, Dar Es Salaam, Tanzania; 5.Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania; 6.Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA; 7.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA; 8.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA; 9.Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London, England; 10.Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA |
推荐引用方式 GB/T 7714 | Wylie, Blair J.,Matechi, Emmanuel,Kishashu, Yahya,et al. Placental Pathology Associated with Household Air Pollution in a Cohort of Pregnant Women from Dar es Salaam, Tanzania[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(1). |
APA | Wylie, Blair J..,Matechi, Emmanuel.,Kishashu, Yahya.,Fawzi, Wafaie.,Premji, Zul.,...&Roberts, Drucilla J..(2017).Placental Pathology Associated with Household Air Pollution in a Cohort of Pregnant Women from Dar es Salaam, Tanzania.ENVIRONMENTAL HEALTH PERSPECTIVES,125(1). |
MLA | Wylie, Blair J.,et al."Placental Pathology Associated with Household Air Pollution in a Cohort of Pregnant Women from Dar es Salaam, Tanzania".ENVIRONMENTAL HEALTH PERSPECTIVES 125.1(2017). |
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