Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1374 |
Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study | |
Nassan, Feiby L.1; Coull, Brent A.2; Gaskins, Audrey J.3,4,5; Williams, Michelle A.6; Skakkebaek, Niels E.7,8; Ford, Jennifer B.1; Ye, Xiaoyun9; Calafat, Antonia M.9; Braun, Joseph M.10; Hauser, Russ1,5,6,11 | |
2017-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark |
英文摘要 | BACKGROUND: Personal care products (PCPs) are exposure sources to phthalates and parabens; however,their contribution to men's exposure is understudied. OBJECTIVES: We examined the association between PCP use and urinary concentrations of phthalate metabolites and parabens in men. METHODS: In a prospective cohort, at multiple study visits, men self-reported their use of 14 PCPs and provided a mine sample (2004-2015, Boston, MA). We measured urinary concentrations of 9 phthalate metabolites and methylparaben, propylparaben, and butylparaben. We estimated the covariate-adjusted percent change in urinary concentrations associated with PCP use using linear mixed and Tobit mixed regressions. We also estimated weights for each PCP in a weighted binary score regression and modeled the resulting composite weighted PCP use. RESULTS: Four hundred men contributed 1,037 urine samples (mean of 3/man). The largest percent increase in monoethyl phthalate (MEP) was associated with use of cologne/perfume (83%, p-value <0.01) and deodorant (74%, p-value <0.01). In contrast, the largest percent increase for parabens was associated with the use of suntan/sunblock lotion (66-156%) and hand/hody lotion (79-147%). Increases in MEP and parabens were generally greater with PCP use within 6 h of urine collection. A subset of 10 PCPs that were used within 6 h of urine collection contributed to at least 70% of the weighted score and predicted a 254-1,333% increase in MEP and parabens concentrations. Associations between PCP use and concentrations of the other phthalate metabolites were not statistically significant. CONCLUSIONS: We identified 10 PCPs of relevance and demonstrated that heir use within 6 h of urine collection strongly predicted MEP and paraben urinary concentrations. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413790600022 |
WOS关键词 | BODY TOPICAL APPLICATION ; DIETHYL PHTHALATE ; BUTYL PARABEN ; EXPOSURE ; CHEMICALS ; PHENOLS ; QUANTIFICATION ; BIOMARKERS ; SAMPLES ; WOMEN |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22719 |
专题 | 资源环境科学 |
作者单位 | 1.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave,Bldg 1,Room 1406, Boston, MA 02115 USA; 2.Harvard TH Chan Sch Publ Hlth, Dept Biostat, 665 Huntington Ave,Bldg 1,Room 1406, Boston, MA 02115 USA; 3.Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 1,Room 1406, Boston, MA 02115 USA; 4.Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; 5.Harvard Med Sch, Boston, MA USA; 6.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 665 Huntington Ave,Bldg 1,Room 1406, Boston, MA 02115 USA; 7.Univ Copenhagen, Dept Growth & Reprod, Copenhagen, Denmark; 8.Univ Copenhagen, EDMaRC, Rigshosp, Copenhagen, Denmark; 9.Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA; 10.Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA; 11.Massachusetts Gen Hosp, Vincent Obstet & Gynecol, Boston, MA 02114 USA |
推荐引用方式 GB/T 7714 | Nassan, Feiby L.,Coull, Brent A.,Gaskins, Audrey J.,et al. Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(8). |
APA | Nassan, Feiby L..,Coull, Brent A..,Gaskins, Audrey J..,Williams, Michelle A..,Skakkebaek, Niels E..,...&Hauser, Russ.(2017).Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(8). |
MLA | Nassan, Feiby L.,et al."Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment And Reproductive Health (EARTH) Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.8(2017). |
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