Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaw1629 |
Host monitoring of quorum sensing during Pseudomonas aeruginosa infection | |
Moura-Alves, Pedro1,2; Puyskens, Andreas1; Stinn, Anne1,3,4,5; Klemm, Marion1; Guhlich-Bornhof, Ute1; Dorhoi, Anca1,6,7; Furkert, Jens8; Kreuchwig, Annika8; Protze, Jonas8; Lozza, Laura1,9; Pei, Gang1; Saikali, Philippe1; Perdomo, Carolina1; Mollenkopf, Hans J.10; Hurwitz, Robert11; Kirschhoefer, Frank12; Brenner-Weiss, Gerald11; Weiner, January, III1,14; Oschkinat, Hartmut8; Kolbe, Michael3,4,5; Krause, Gerd8; Kaufmann, Stefan H. E.1,13 | |
2019-12-20 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6472页码:1472-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; England; USA |
英文摘要 | Pseudomonas aeruginosa rapidly adapts to altered conditions by quorum sensing (QS), a communication system that it uses to collectively modify its behavior through the production, release, and detection of signaling molecules. QS molecules can also be sensed by hosts, although the respective receptors and signaling pathways are poorly understood. We describe a pattern of regulation in the host by the aryl hydrocarbon receptor (AhR) that is critically dependent on qualitative and quantitative sensing of P. aeruginosa quorum. QS molecules bind to AhR and distinctly modulate its activity. This is mirrored upon infection with P. aeruginosa collected from diverse growth stages and with QS mutants. We propose that by spying on bacterial quorum, AhR acts as a major sensor of infection dynamics, capable of orchestrating host defense according to the status quo of infection. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000503861000046 |
WOS关键词 | ARYL-HYDROCARBON RECEPTOR ; N-3-OXODODECANOYL HOMOSERINE LACTONE ; LIGAND BINDING DOMAIN ; NF-KAPPA-B ; EXPRESSION ; MODEL ; COMMUNICATION ; MOLECULES ; ZEBRAFISH ; RESPONSES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226500 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Max Planck Inst Infect Biol, Dept Immunol, D-10117 Berlin, Germany; 2.Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England; 3.Max Planck Inst Infect Biol, Struct Syst Biol, D-10117 Berlin, Germany; 4.Helmholtz Ctr Infect Res HZI, Dept Struct Infect Biol, Ctr Struct Syst Biol, D-22607 Hamburg, Germany; 5.Univ Hamburg, Fac Math Informat & Nat Sci, D-20148 Hamburg, Germany; 6.Friedrich Loeffler Inst, Inst Immunol, Greifswald, Germany; 7.Ernst Moritz Arndt Univ Greifswald, Fac Math & Nat Sci, Greifswald, Germany; 8.Leibniz Forsch Inst Mol Pharmakol FMP, D-13125 Berlin, Germany; 9.Epiontis GmbH Precis Med, D-12489 Berlin, Germany; 10.Max Planck Inst Infect Biol, Dept Immunol, Microarray Core Facil, D-10117 Berlin, Germany; 11.Max Planck Inst Infect Biol, Prot Purificat Core Facil, D-10117 Berlin, Germany; 12.Karlsruhe Inst Technol, Inst Funct Interfaces, Karlsruhe, Germany; 13.Texas A&M Univ, Hagler Inst Adv Study, College Stn, TX 77843 USA; 14.Berlin Inst Hlth, Core Unit Bioinformat, D-10117 Berlin, Germany |
推荐引用方式 GB/T 7714 | Moura-Alves, Pedro,Puyskens, Andreas,Stinn, Anne,et al. Host monitoring of quorum sensing during Pseudomonas aeruginosa infection[J]. SCIENCE,2019,366(6472):1472-+. |
APA | Moura-Alves, Pedro.,Puyskens, Andreas.,Stinn, Anne.,Klemm, Marion.,Guhlich-Bornhof, Ute.,...&Kaufmann, Stefan H. E..(2019).Host monitoring of quorum sensing during Pseudomonas aeruginosa infection.SCIENCE,366(6472),1472-+. |
MLA | Moura-Alves, Pedro,et al."Host monitoring of quorum sensing during Pseudomonas aeruginosa infection".SCIENCE 366.6472(2019):1472-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论