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DOI | 10.1126/science.aax9198 |
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells | |
Uhlen, Mathias1,2,3; Karlsson, Max J.1; Zhong, Wen1; Tebani, Abdellah1; Pou, Christian4; Mikes, Jaromir4; Lakshmikanth, Tadepally4; Forsstrom, Bjorn1; Edfors, Fredrik1; Odeberg, Jacob1,5; Mardinoglu, Adil1,6; Zhang, Cheng1; von Feilitzen, Kalle1; Mulder, Jan2; Sjostedt, Evelina2; Hober, Andreas1; Oksvold, Per1; Zwahlen, Martin1; Ponten, Fredrik7; Lindskog, Cecilia7; Sivertsson, Asa1; Fagerberg, Linn1; Brodin, Petter4,8 | |
2019-12-20 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6472页码:1471-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; Denmark; England |
英文摘要 | Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000503861000045 |
WOS关键词 | RNA-SEQ ; IMMUNE-SYSTEM ; EXPRESSION ; VISUALIZATION ; ASSOCIATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226499 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden; 2.Karolinska Inst, Dept Neurosci, Stockholm, Sweden; 3.Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, Lyngby, Denmark; 4.Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Stockholm, Sweden; 5.Karolinska Univ Hosp, Coagulat Unit, Dept Hematol, Stockholm, Sweden; 6.Kings Coll London, Ctr Host Microbiome Interact, Fac Dent Oral & Craniofacial Sci, London, England; 7.Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden; 8.Karolinska Univ Hosp, Unit Pediat Rheumatol, Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Uhlen, Mathias,Karlsson, Max J.,Zhong, Wen,et al. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells[J]. SCIENCE,2019,366(6472):1471-+. |
APA | Uhlen, Mathias.,Karlsson, Max J..,Zhong, Wen.,Tebani, Abdellah.,Pou, Christian.,...&Brodin, Petter.(2019).A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.SCIENCE,366(6472),1471-+. |
MLA | Uhlen, Mathias,et al."A genome-wide transcriptomic analysis of protein-coding genes in human blood cells".SCIENCE 366.6472(2019):1471-+. |
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