GSTDTAP
DOI10.1126/science.aax9198
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells
Uhlen, Mathias1,2,3; Karlsson, Max J.1; Zhong, Wen1; Tebani, Abdellah1; Pou, Christian4; Mikes, Jaromir4; Lakshmikanth, Tadepally4; Forsstrom, Bjorn1; Edfors, Fredrik1; Odeberg, Jacob1,5; Mardinoglu, Adil1,6; Zhang, Cheng1; von Feilitzen, Kalle1; Mulder, Jan2; Sjostedt, Evelina2; Hober, Andreas1; Oksvold, Per1; Zwahlen, Martin1; Ponten, Fredrik7; Lindskog, Cecilia7; Sivertsson, Asa1; Fagerberg, Linn1; Brodin, Petter4,8
2019-12-20
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2019
卷号366期号:6472页码:1471-+
文章类型Article
语种英语
国家Sweden; Denmark; England
英文摘要

Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000503861000045
WOS关键词RNA-SEQ ; IMMUNE-SYSTEM ; EXPRESSION ; VISUALIZATION ; ASSOCIATION
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/226499
专题环境与发展全球科技态势
作者单位1.KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden;
2.Karolinska Inst, Dept Neurosci, Stockholm, Sweden;
3.Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, Lyngby, Denmark;
4.Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Stockholm, Sweden;
5.Karolinska Univ Hosp, Coagulat Unit, Dept Hematol, Stockholm, Sweden;
6.Kings Coll London, Ctr Host Microbiome Interact, Fac Dent Oral & Craniofacial Sci, London, England;
7.Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden;
8.Karolinska Univ Hosp, Unit Pediat Rheumatol, Stockholm, Sweden
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GB/T 7714
Uhlen, Mathias,Karlsson, Max J.,Zhong, Wen,et al. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells[J]. SCIENCE,2019,366(6472):1471-+.
APA Uhlen, Mathias.,Karlsson, Max J..,Zhong, Wen.,Tebani, Abdellah.,Pou, Christian.,...&Brodin, Petter.(2019).A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.SCIENCE,366(6472),1471-+.
MLA Uhlen, Mathias,et al."A genome-wide transcriptomic analysis of protein-coding genes in human blood cells".SCIENCE 366.6472(2019):1471-+.
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