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DOI | 10.1126/science.aax9176 |
A metagenomic strategy for harnessing the chemical repertoire of the human microbiome | |
Sugimoto, Yuki1; Camacho, Francine R.2; Wang, Shuo3; Chankhamjon, Pranatchareeya1; Odabas, Arman1; Biswas, Abhishek1,4; Jeffrey, Philip D.1; Donia, Mohamed S.1 | |
2019-12-13 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6471页码:1332-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Extensive progress has been made in determining the effects of the microbiome on human physiology and disease, but the underlying molecules and mechanisms governing these effects remain largely unexplored. Here, we combine a new computational algorithm with synthetic biology to access biologically active small molecules encoded directly in human microbiome-derived metagenomic sequencing data. We discover that members of a clinically used class of molecules are widely encoded in the human microbiome and that they exert potent antibacterial activities against neighboring microbes, implying a possible role in niche competition and host defense. Our approach paves the way toward a systematic unveiling of the chemical repertoire encoded by the human microbiome and provides a generalizable platform for discovering molecular mediators of microbiome-host and microbiome-microbiome interactions. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000502802300049 |
WOS关键词 | GUT MICROBIOTA ; STREPTOMYCES ; GENOME ; ELLORAMYCIN ; DIVERSITY ; DISCOVERY ; PRODUCTS ; DYNAMICS ; RESOURCE ; BACTERIA |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226438 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA; 2.Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA; 3.Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA; 4.Princeton Univ, Off Informat Technol, Res Comp, Princeton, NJ 08544 USA |
推荐引用方式 GB/T 7714 | Sugimoto, Yuki,Camacho, Francine R.,Wang, Shuo,et al. A metagenomic strategy for harnessing the chemical repertoire of the human microbiome[J]. SCIENCE,2019,366(6471):1332-+. |
APA | Sugimoto, Yuki.,Camacho, Francine R..,Wang, Shuo.,Chankhamjon, Pranatchareeya.,Odabas, Arman.,...&Donia, Mohamed S..(2019).A metagenomic strategy for harnessing the chemical repertoire of the human microbiome.SCIENCE,366(6471),1332-+. |
MLA | Sugimoto, Yuki,et al."A metagenomic strategy for harnessing the chemical repertoire of the human microbiome".SCIENCE 366.6471(2019):1332-+. |
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