Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aav1282 |
Depletion of microbiome-derived molecules in the host using Clostridium genetics | |
Guo, Chun-Jun1,2,3; Allen, Breanna M.4,5,6; Hiam, Kamir J.4,5,6; Dodd, Dylan7,8; Van Treuren, Will6,8; Higginbottom, Steven6,8; Nagashima, Kazuki1,2; Fischer, Curt R.1,2,6; Sonnenburg, Justin L.6,8; Spitzer, Matthew H.4,5,6; Fischbach, Michael A.1,2,6 | |
2019-12-13 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6471页码:1331-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The gut microbiota produce hundreds of molecules that are present at high concentrations in the host circulation. Unraveling the contribution of each molecule to host biology remains difficult. We developed a system for constructing clean deletions in Clostridium spp., the source of many molecules from the gut microbiome. By applying this method to the model commensal organism Clostridium sporogenes, we knocked out genes for 10 C. sporogenes-derived molecules that accumulate in host tissues. In mice colonized by a C. sporogenes for which the production of branched short-chain fatty acids was knocked out, we discovered that these microbial products have immunoglobulin A-modulatory activity. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000502802300048 |
WOS关键词 | CHAIN FATTY-ACIDS ; PYRUVATE-FERREDOXIN OXIDOREDUCTASE ; STABLE-ISOTOPE DILUTION ; TRIMETHYLAMINE-N-OXIDE ; AROMATIC-AMINO-ACIDS ; GUT MICROBIOTA ; FERMENTATION ; BEIJERINCKII ; METABOLITES ; DELETION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226437 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 2.Stanford Univ, ChEM H Inst, Stanford, CA 94305 USA; 3.Weill Cornell Med, Jill Roberts Inst Res Inflammatory Bowel Dis, Dept Med, New York, NY 10021 USA; 4.Univ Calif San Francisco, Parker Inst Canc Immunotherapy, Helen Diller Family Comprehens Canc Ctr, Dept Otolaryngol,Grad Program Biomed Sci, San Francisco, CA 94143 USA; 5.Univ Calif San Francisco, Parker Inst Canc Immunotherapy, Helen Diller Family Comprehens Canc Ctr, Dept Microbiol & Immunol,Grad Program Biomed Sci, San Francisco, CA 94143 USA; 6.Chan Zuckerberg Biohub, San Francisco, CA 94158 USA; 7.Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA; 8.Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Guo, Chun-Jun,Allen, Breanna M.,Hiam, Kamir J.,et al. Depletion of microbiome-derived molecules in the host using Clostridium genetics[J]. SCIENCE,2019,366(6471):1331-+. |
APA | Guo, Chun-Jun.,Allen, Breanna M..,Hiam, Kamir J..,Dodd, Dylan.,Van Treuren, Will.,...&Fischbach, Michael A..(2019).Depletion of microbiome-derived molecules in the host using Clostridium genetics.SCIENCE,366(6471),1331-+. |
MLA | Guo, Chun-Jun,et al."Depletion of microbiome-derived molecules in the host using Clostridium genetics".SCIENCE 366.6471(2019):1331-+. |
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