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DOI | 10.1126/science.aay2783 |
Structures of the AMPA receptor incomplex with its auxiliary subunit cornichon | |
Nakagawa, Terunaga1,2 | |
2019-12-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6470页码:1259-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | In the brain, AMPA-type glutamate receptors (AMPARs) form complexes with their auxiliary subunits and mediate the majority of fast excitatory neurotransmission. Signals transduced by these complexes are critical for synaptic plasticity, learning, and memory. The two major categories of AMPAR auxiliary subunits are transmembrane AMPAR regulatory proteins (TARPs) and cornichon homologs (CNIHs); these subunits share little homology and play distinct roles in controlling ion channel gating and trafficking of AMPAR. Here, I report high-resolution cryo-electron microscopy structures of AMPAR in complex with CNIH3. Contrary to its predicted membrane topology, CNIH3 lacks an extracellular domain and instead contains four membrane-spanning helices. The protein-protein interaction interface that dictates channel modulation and the lipids surrounding the complex are revealed. These structures provide insights into the molecular mechanism for ion channel modulation and assembly of AMPAR/CNIH3 complexes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000502662500061 |
WOS关键词 | IONOTROPIC GLUTAMATE RECEPTORS ; ACTIVATION ; MECHANISM ; DESENSITIZATION ; TRANSMISSION ; MODULATION ; PROTEINS ; TARPS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226385 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Vanderbilt Univ, Dept Mol Physiol & Biophys, Struct Biol Ctr, Sch Med, Nashville, TN 37232 USA; 2.Vanderbilt Univ, Sch Med, Vanderbilt Brain Inst, Nashville, TN 37232 USA |
推荐引用方式 GB/T 7714 | Nakagawa, Terunaga. Structures of the AMPA receptor incomplex with its auxiliary subunit cornichon[J]. SCIENCE,2019,366(6470):1259-+. |
APA | Nakagawa, Terunaga.(2019).Structures of the AMPA receptor incomplex with its auxiliary subunit cornichon.SCIENCE,366(6470),1259-+. |
MLA | Nakagawa, Terunaga."Structures of the AMPA receptor incomplex with its auxiliary subunit cornichon".SCIENCE 366.6470(2019):1259-+. |
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