Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aay4509 |
Stem cell-driven lymphatic remodeling coordinates tissue regeneration | |
Gur-Cohen, Shiri1; Yang, Hanseul1; Baksh, Sanjeethan C.1; Miao, Yuxuan1; Levorse, John1; Kataru, Raghu P.2; Liu, Xiaolei3; de la Cruz-Racelis, June1; Mehrara, Babak J.2; Fuchs, Elaine1 | |
2019-12-06 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6470页码:1218-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Tissues rely on stem cells (SCs) for homeostasis and wound repair. SCs reside in specialized microenvironments (niches) whose complexities and roles in orchestrating tissue growth are still unfolding. Here, we identify lymphatic capillaries as critical SC-niche components. In skin, lymphatics form intimate networks around hair follicle (HF) SCs. When HFs regenerate, lymphatic-SC connections become dynamic. Using a mouse model, we unravel a secretome switch in SCs that controls lymphatic behavior. Resting SCs express angiopoietin-like protein 7 (Angptl7), promoting lymphatic drainage. Activated SCs switch to Angptl4, triggering transient lymphatic dissociation and reduced drainage. When lymphatics are perturbed or the secretome switch is disrupted, HFs cycle precociously and tissue regeneration becomes asynchronous. In unearthing lymphatic capillaries as a critical SC-niche element, we have learned how SCs coordinate their activity across a tissue. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000502662500052 |
WOS关键词 | HEMATOPOIETIC STEM ; PROGENITOR CELLS ; SKIN ; NICHES ; LYMPHANGIOGENESIS ; VASCULATURE ; MAINTENANCE ; PLASTICITY ; NETRINS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226376 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Rockefeller Univ, Howard Hughes Med Inst, Robin Chemers Neustein Lab Mammalian Cell Biol &, New York, NY 10065 USA; 2.Mem Sloan Kettering Canc Ctr, Dept Surg, Plast & Reconstruct Surg Serv, New York, NY 10065 USA; 3.Northwestern Univ, Ctr Vasc & Dev Biol, Feinberg Cardiovasc & Renal Res Inst, Chicago, IL 60611 USA |
推荐引用方式 GB/T 7714 | Gur-Cohen, Shiri,Yang, Hanseul,Baksh, Sanjeethan C.,et al. Stem cell-driven lymphatic remodeling coordinates tissue regeneration[J]. SCIENCE,2019,366(6470):1218-+. |
APA | Gur-Cohen, Shiri.,Yang, Hanseul.,Baksh, Sanjeethan C..,Miao, Yuxuan.,Levorse, John.,...&Fuchs, Elaine.(2019).Stem cell-driven lymphatic remodeling coordinates tissue regeneration.SCIENCE,366(6470),1218-+. |
MLA | Gur-Cohen, Shiri,et al."Stem cell-driven lymphatic remodeling coordinates tissue regeneration".SCIENCE 366.6470(2019):1218-+. |
条目包含的文件 | 条目无相关文件。 |
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