Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aay1186 |
A cortical-brainstem circuit predicts and governs compulsive alcohol drinking | |
Siciliano, Cody A.1,2,3; Noamany, Habiba1; Chang, Chia-Jung1; Brown, Alex R.1,2,3; Chen, Xinhong1; Leible, Daniel1; Lee, Jennifer J.1; Wang, Joyce1; Vernon, Amanda N.1; Vander Weele, Caitlin M.1; Kimchi, Eyal Y.1; Heiman, Myriam1; Tye, Kay M.1,4 | |
2019-11-22 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6468页码:1008-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | What individual differences in neural activity predict the future escalation of alcohol drinking from casual to compulsive? The neurobiological mechanisms that gate the transition from moderate to compulsive drinking remain poorly understood. We longitudinally tracked the development of compulsive drinking across a binge-drinking experience in male mice. Binge drinking unmasked individual differences, revealing latent traits in alcohol consumption and compulsive drinking despite equal prior exposure to alcohol. Distinct neural activity signatures of cortical neurons projecting to the brainstem before binge drinking predicted the ultimate emergence of compulsivity. Mimicry of activity patterns that predicted drinking phenotypes was sufficient to bidirectionally modulate drinking. Our results provide a mechanistic explanation for individual variance in vulnerability to compulsive alcohol drinking. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000498849000044 |
WOS关键词 | PREFRONTAL CORTEX ; ETHANOL DRINKING ; RESPONSE-INHIBITION ; DRUG-SEEKING ; ACTIVATION ; NEURONS ; MODEL ; ADOLESCENTS ; WITHDRAWAL ; AVERSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226248 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.MIT, Dept Brain & Cognit Sci, Picower Inst Learning & Memory, E25-618, Cambridge, MA 02139 USA; 2.Vanderbilt Univ, Dept Pharmacol, Sch Med, Nashville, TN 37232 USA; 3.Vanderbilt Univ, Sch Med, Vanderbilt Ctr Addict Res, Nashville, TN 37232 USA; 4.Salk Inst Biol Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA |
推荐引用方式 GB/T 7714 | Siciliano, Cody A.,Noamany, Habiba,Chang, Chia-Jung,et al. A cortical-brainstem circuit predicts and governs compulsive alcohol drinking[J]. SCIENCE,2019,366(6468):1008-+. |
APA | Siciliano, Cody A..,Noamany, Habiba.,Chang, Chia-Jung.,Brown, Alex R..,Chen, Xinhong.,...&Tye, Kay M..(2019).A cortical-brainstem circuit predicts and governs compulsive alcohol drinking.SCIENCE,366(6468),1008-+. |
MLA | Siciliano, Cody A.,et al."A cortical-brainstem circuit predicts and governs compulsive alcohol drinking".SCIENCE 366.6468(2019):1008-+. |
条目包含的文件 | 条目无相关文件。 |
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