Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aav3487 |
Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy | |
Gil-Cruz, Cristina1; Perez-Shibayama, Christian1; De Martin, Angelina1; Ronchi, Francesca2; van der Borght, Katrien3; Niederer, Rebekka1; Onder, Lucas1; Lutge, Mechthild1; Novkovic, Mario1; Nindl, Veronika1; Ramos, Gustavo4,5; Arnoldini, Markus6; Slack, Emma M. C.6; Boivin-Jahns, Valerie5,7; Jahns, Roland5,8; Wyss, Madeleine9; Mooser, Catherine2; Lambrecht, Bart N.3; Maeder, Micha T.10; Rickli, Hans10; Flatz, Lukas1; Eriksson, Urs11,12; Geuking, Markus B.13; Mccoy, Kathy D.9; Ludewig, Burkhard1 | |
2019-11-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6467页码:881-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; Belgium; Germany; Canada |
英文摘要 | Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6-specific T helper (T-H)1 and T(H)17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T cells have remained elusive. Using a mouse model of spontaneous autoimmune myocarditis, we show that progression of myocarditis to lethal heart disease depends on cardiac myosin-specific T(H)17 cells imprinted in the intestine by a commensal Bacteroides species peptide mimic. Both the successful prevention of lethal disease in mice by antibiotic therapy and the significantly elevated Bacteroides-specific CD4(+) T cell and B cell responses observed in human myocarditis patients suggest that mimic peptides from commensal bacteria can promote inflammatory cardiomyopathy in genetically susceptible individuals. The ability to restrain cardiotoxic T cells through manipulation of the microbiome thereby transforms inflammatory cardiomyopathy into a targetable disease. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000496946200056 |
WOS关键词 | DILATED CARDIOMYOPATHY ; AUTOIMMUNE MYOCARDITIS ; CELLS ; RESPONSES ; HEART |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226240 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Kantonsspital St Gallen, Inst Immunobiol, St Gallen, Switzerland; 2.Univ Bern, Inselspital, Univ Klin Viszerale Chirurg & Med, Maurice Muller Labs,Dept Biomed Res, Bern, Switzerland; 3.Univ Ghent, Dept Internal Med & Pediat, VIB Ctr Inflammat Res, Ghent, Belgium; 4.Univ Hosp Wurzburg, Dept Internal Med 1, Wurzburg, Germany; 5.Univ Hosp Wurzburg, Comprehens Heart Failure Ctr, Wurzburg, Germany; 6.ETH, Inst Food Nutr & Hlth, Zurich, Switzerland; 7.Univ Wurzburg, Inst Pharmacol & Toxicol, Wurzburg, Germany; 8.Univ Hosp Wurzburg, Interdisciplinary Bank Biomat & Data Wurzburg IBD, Wurzburg, Germany; 9.Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Dept Physiol & Pharmacol, Calgary, AB, Canada; 10.Kantonsspital St Gallen, Div Cardiol, St Gallen, Switzerland; 11.Univ Zurich, Ctr Mol Cardiol, Zurich, Switzerland; 12.GZO Reg Hlth Ctr, Dept Med, Wetzikon, Switzerland; 13.Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada |
推荐引用方式 GB/T 7714 | Gil-Cruz, Cristina,Perez-Shibayama, Christian,De Martin, Angelina,et al. Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy[J]. SCIENCE,2019,366(6467):881-+. |
APA | Gil-Cruz, Cristina.,Perez-Shibayama, Christian.,De Martin, Angelina.,Ronchi, Francesca.,van der Borght, Katrien.,...&Ludewig, Burkhard.(2019).Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy.SCIENCE,366(6467),881-+. |
MLA | Gil-Cruz, Cristina,et al."Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy".SCIENCE 366.6467(2019):881-+. |
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