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DOI | 10.1126/science.aax1694 |
Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function | |
de Morree, Antoine1,2; Klein, Julian D. D.1,2; Gan, Qiang1,2; Farup, Jean1,2,3,4; Urtasun, Andoni1,2; Kanugovi, Abhijnya1,2; Bilen, Biter1,2; van Velthoven, Cindy T. J.1,2,6; Quarta, Marco1,2,5,7; Rando, Thomas A.1,2,5 | |
2019-11-08 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6466页码:734-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark |
英文摘要 | Adult stem cells are essential for tissue homeostasis. In skeletal muscle, muscle stem cells (MuSCs) reside in a quiescent state, but little is known about the mechanisms that control homeostatic turnover. Here we show that, in mice, the variation in MuSC activation rate among different muscles (for example, limb versus diaphragm muscles) is determined by the levels of the transcription factor Pax3. We further show that Pax3 levels are controlled by alternative polyadenylation of its transcript, which is regulated by the small nucleolar RNA U1. Isoforms of the Pax3 messenger RNA that differ in their 3' untranslated regions are differentially susceptible to regulation by microRNA miR206, which results in varying levels of the Pax3 protein in vivo. These findings highlight a previously unrecognized mechanism of the homeostatic regulation of stem cell fate by multiple RNA species. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000496500400048 |
WOS关键词 | SATELLITE CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226183 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA; 2.Stanford Univ, Sch Med, Paul F Glenn Ctr Biol Aging, Stanford, CA 94305 USA; 3.Aarhus Univ, Res Lab Biochem Pathol, Dept Clin Med, Aarhus, Denmark; 4.Aarhus Univ, Res Lab Biochem Pathol, Dept Biomed, Aarhus, Denmark; 5.Vet Affairs Palo Alto Hlth Care Syst, Ctr Tissue Regenerat Repair & Restorat, Palo Alto, CA 94304 USA; 6.Allen Inst Brain Sci, Seattle, WA USA; 7.Mol Med Res Inst, Sunnyvale, CA USA |
推荐引用方式 GB/T 7714 | de Morree, Antoine,Klein, Julian D. D.,Gan, Qiang,et al. Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function[J]. SCIENCE,2019,366(6466):734-+. |
APA | de Morree, Antoine.,Klein, Julian D. D..,Gan, Qiang.,Farup, Jean.,Urtasun, Andoni.,...&Rando, Thomas A..(2019).Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function.SCIENCE,366(6466),734-+. |
MLA | de Morree, Antoine,et al."Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function".SCIENCE 366.6466(2019):734-+. |
条目包含的文件 | 条目无相关文件。 |
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