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DOI | 10.1126/science.aax5440 |
Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep | |
Fultz, Nina E.1,2; Bonmassar, Giorgio2,3; Setsompop, Kawin2,3; Stickgold, Robert A.4,5; Rosen, Bruce R.2,3; Polimeni, Jonathan R.2,3; Lewis, Laura D.1,2 | |
2019-11-01 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6465页码:628-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related is not known. We used accelerated neuroimaging to measure physiological and neural dynamics in the human brain. We discovered a coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non-rapid eye movement sleep. Neural slow waves are followed by hemodynamic oscillations, which in turn are coupled to CSF flow. These results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and these CSF dynamics are interlinked with neural and hemodynamic rhythms. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000494465700047 |
WOS关键词 | BRAIN ACTIVITY ; RESTING-STATE ; FUNCTIONAL CONNECTIVITY ; NEURAL ACTIVITY ; REFERENCE LAYER ; FMRI ; FLUCTUATIONS ; ARTIFACT ; ENTRAINMENT ; TRANSPORT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226132 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA; 2.Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Boston, MA 02129 USA; 3.Harvard Med Sch, Dept Radiol, Boston, MA 02115 USA; 4.Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA 02215 USA; 5.Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Fultz, Nina E.,Bonmassar, Giorgio,Setsompop, Kawin,et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep[J]. SCIENCE,2019,366(6465):628-+. |
APA | Fultz, Nina E..,Bonmassar, Giorgio.,Setsompop, Kawin.,Stickgold, Robert A..,Rosen, Bruce R..,...&Lewis, Laura D..(2019).Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep.SCIENCE,366(6465),628-+. |
MLA | Fultz, Nina E.,et al."Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep".SCIENCE 366.6465(2019):628-+. |
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