Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aan4673 |
Clonal hematopoiesis in human aging and disease | |
Jaiswal, Siddhartha1; Ebert, Benjamin L.2,3 | |
2019-11-01 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2019 |
卷号 | 366期号:6465页码:586-+ |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | As people age, their tissues accumulate an increasing number of somatic mutations. Although most of these mutations are of little or no functional consequence, a mutation may arise that confers a fitness advantage on a cell. When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated stem cell. This outgrowth, called "clonal hematopoiesis," is highly prevalent in the elderly population. Here we discuss recent advances in our knowledge of clonal hematopoiesis, its relationship to malignancies, its link to nonmalignant diseases of aging, and its potential impact on immune function. Clonal hematopoiesis provides a glimpse into the process of mutation and selection that likely occurs in all somatic tissues. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000494465700037 |
WOS关键词 | ACUTE MYELOID-LEUKEMIA ; STEM-CELLS ; SOMATIC MUTATIONS ; MYELOGENOUS LEUKEMIA ; DRIVER MUTATIONS ; DNMT3A MUTATIONS ; GENE-EXPRESSION ; CANCER-RISK ; TET2 ; AGE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/226122 |
专题 | 环境与发展全球科技态势 |
作者单位 | 1.Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA; 2.Howard Hughes Med Inst, Dept Med Oncol, Boston, MA 02115 USA; 3.MIT & Harvard, Broad Inst, Cambridge, MA 02142 USA |
推荐引用方式 GB/T 7714 | Jaiswal, Siddhartha,Ebert, Benjamin L.. Clonal hematopoiesis in human aging and disease[J]. SCIENCE,2019,366(6465):586-+. |
APA | Jaiswal, Siddhartha,&Ebert, Benjamin L..(2019).Clonal hematopoiesis in human aging and disease.SCIENCE,366(6465),586-+. |
MLA | Jaiswal, Siddhartha,et al."Clonal hematopoiesis in human aging and disease".SCIENCE 366.6465(2019):586-+. |
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