Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP275 |
Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds | |
Grandjean, Philippe1,2; Heilmann, Carsten3; Weihe, Pal4; Nielsen, Flemming1; Mogensen, Ulla B.5; Budtz-Jorgensen, Esben5 | |
2017-07-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:7 |
文章类型 | Article |
语种 | 英语 |
国家 | Denmark; USA |
英文摘要 | BACKGROUND: Postnatal exposure to perfluorinated alkylate substances (PFASs) is associated with lower serum concentrations of specific antibodies against certain childhood vaccines at 7 y. OBJECTIVES: We prospectively followed a Faroese birth cohort to determine these associations at 13 y. METHODS: In 516 subjects (79% of eligible cohort members) who were 13 years old, serum concentrations of PFASs and of antibodies against diphtheria and tetanus were measured and were compared with data from the previous examination at 7 y. Multiple regression analyses and structural equation models were applied to determine the association between postnatal PEAS exposures and antibody concentrations. RESULTS: Serum concentrations of PFASs and antibodies generally declined from 7 y to 13 y. However, 68 subjects had visited the emergency room and had likely received a vaccination booster, and a total of 202 children showed higher vaccine antibody concentrations at 13 y than at 7 y. Therefore, separate analyses were conducted after exclusion of these two subgroups. Diphtheria antibody concentrations decreased at elevated PFAS concentrations at 13 y and 7 y; the associations were statistically significant for perfluorodecanoate (PFDA) at 7 y and for perfluorooctanoate (PFDA) at 13 y, both suggesting a decrease by similar to 25% for each doubling of exposure. Structural equation models showed that a doubling in PFAS exposure at 7 y was associated with losses in diphtheria antibody concentrations at 13 y of 10-30% for the live PFASs. Few associations were observed for anti tetanus concentrations. CONCLUSIONS: These results are in accord with previous findings of PFAS immunotoxicity at current exposure levels. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413791300026 |
WOS关键词 | PRENATAL EXPOSURE ; EARLY-CHILDHOOD ; PERFLUOROOCTANESULFONATE ; IMMUNOTOXICITY ; HEALTH ; RISK ; LIFE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22590 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Southern Denmark, Dept Environm Med, Odense, Denmark; 2.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 3.Natl Univ Hosp, Rigshosp, Paediat Clin, Copenhagen, Denmark; 4.Faroese Hosp Syst, Dept Occupat Med & Publ Hlth, Torshavn, Faroe Islands, Denmark; 5.Univ Copenhagen, Dept Biostat, Copenhagen, Denmark |
推荐引用方式 GB/T 7714 | Grandjean, Philippe,Heilmann, Carsten,Weihe, Pal,et al. Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(7). |
APA | Grandjean, Philippe,Heilmann, Carsten,Weihe, Pal,Nielsen, Flemming,Mogensen, Ulla B.,&Budtz-Jorgensen, Esben.(2017).Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds.ENVIRONMENTAL HEALTH PERSPECTIVES,125(7). |
MLA | Grandjean, Philippe,et al."Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds".ENVIRONMENTAL HEALTH PERSPECTIVES 125.7(2017). |
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