Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP1912 |
Associations between Methylated Metabolites of Arsenic and Selenium in Urine of Pregnant Bangladeshi Women and Interactions between the Main Genes Involved | |
Skroder, Helena1; Engstrom, Karin1,2; Kuehnelt, Doris3; Kippler, Maria1; Francesconi, Kevin3; Nermell, Barbro1; Tofail, Fahmida4; Broberg, Karin1; Vahter, Marie1 | |
2018-02-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:2 |
文章类型 | Article |
语种 | 英语 |
国家 | Sweden; Austria; Bangladesh |
英文摘要 | BACKGROUND: It has been proposed that interactions between selenium and arsenic in the body may affect their kinetics and toxicity. However, it is unknown how the elements influence each other in humans. OBJECTIVES: We aimed to investigate potential interactions in the methylation of selenium and arsenic. METHODS: Urinary selenium (U-Se) and arsenic (U-As) were measured using inductively coupled plasma mass spectrometry (ICPMS) in samples collected from pregnant women (n = 226) in rural Bangladesh at gestational weeks (GW) 8, 14, 19, and 30. Urinary concentrations of trimethyl selenonium ion (TMSe) were measured by HPLC-vapor generation-ICPMS, as were inorganic arsenic (iAs), methylarsonic acid (MMA), and dimethylarsinic acid (DMA). IMethylation efficiency was assessed based on relative amounts (%) of arsenic and selenium metabolites in urine. Genotyping for the main arsenite and selenium methyffiansferases, AS3MT and INMT, was performed using TaqMan probes or Sequenom. RESULTS: Multivariable-adjusted linear regression analyses indicated that %TMSe (at GW8) was positively associated with %MMA (beta = 1.3, 95% CI: 0.56, 2.0) and U-As, and inversely associated with %DMA and U-Se in producers of TMSe (INMT rs6970396 AG + AA, n = 7 4), who had a wide range of urinary TMSe, (12-42%). Also, %TMSe decreased in parallel to %MMA during pregnancy, especially in the first trimester (-0.58 %TMSe per gestational week). We found a gene gene interaction for %MMA (p-interaction = 0.076 for haplotype 1). In analysis stratified by INMT genotype, the association between %MMA and both AS3MT haplotypes 1 and 3 was stronger in women with the INMT (TMSe nonproducers, 5th-95th percentile,: 0.2-2%TMSe) vs. AG + AA genotype. CONCLUSIONS: Our findings for Bangladeshi women suggest a positive association between urinary %MMA and %TMSe. Genes involved in the methylation of selenium and arsenic may interact on associations with urinary %MMA. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000424500800002 |
WOS关键词 | METHYLTRANSFERASE AS3MT ; TRIMETHYLSELENONIUM ION ; DRINKING-WATER ; AS-III ; ICP-MS ; EXPOSURE ; POPULATION ; TOXICITY ; RAT ; POLYMORPHISMS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22582 |
专题 | 资源环境科学 |
作者单位 | 1.Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden; 2.Lund Univ, Dept Lab Med, Div Occupat & Environm Med, Lund, Sweden; 3.Karl Franzens Univ Graz, NAWI Graz, Inst Chem, Graz, Austria; 4.Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh |
推荐引用方式 GB/T 7714 | Skroder, Helena,Engstrom, Karin,Kuehnelt, Doris,et al. Associations between Methylated Metabolites of Arsenic and Selenium in Urine of Pregnant Bangladeshi Women and Interactions between the Main Genes Involved[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(2). |
APA | Skroder, Helena.,Engstrom, Karin.,Kuehnelt, Doris.,Kippler, Maria.,Francesconi, Kevin.,...&Vahter, Marie.(2018).Associations between Methylated Metabolites of Arsenic and Selenium in Urine of Pregnant Bangladeshi Women and Interactions between the Main Genes Involved.ENVIRONMENTAL HEALTH PERSPECTIVES,126(2). |
MLA | Skroder, Helena,et al."Associations between Methylated Metabolites of Arsenic and Selenium in Urine of Pregnant Bangladeshi Women and Interactions between the Main Genes Involved".ENVIRONMENTAL HEALTH PERSPECTIVES 126.2(2018). |
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