Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP864 |
Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study | |
Le Cornet, Charlotte1,2; Fervers, Beatrice3,4; Pukkala, Eero5,6; Tynes, Tore7,8; Feychting, Maria9; Hansen, Johnni10; Togawa, Kayo1; Nordby, Karl-Christian8; Dalton, Susanne Oksbjerg10; Uuksulainen, Sanni11; Wiebert, Pernilla12; Woldbaek, Torill8; Skakkebaek, Niels E.13; Olsson, Ann1,12; Schuz, Joachim1 | |
2017-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | France; Germany; Finland; Norway; Sweden; Denmark |
英文摘要 | BACKGROUND: Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development in utero. OBJECTIVES: We aimed to assess the association between maternal and paternal occupational exposures to organic solvents during the prenatal period and TGCT risk in their offspring. METHODS: This registry-based case control study included TGCT cases aged 1449 y (n=8,112) diagnosed from 1978 to 2012 in Finland, Norway, and Sweden. Controls (n=26,264) were randomly selected from the central population registries and were individually matched to cases on year and country of birth. Occupational histories of parents prior to the childs birth were extracted from the national censuses. Job codes were converted into solvent exposure using the Nordic job-Nordic Occupational Cancer Study Job-Exposure Matrix. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Overall, no association was found between prenatal maternal exposure to solvents and TGCT risk. In subset analyses using only mothers for whom occupational information was available in the year of or in the year prior to the childs birth, there was an association with maternal exposure to aromatic hydrocarbon solvents (ARHC) (OR=1.53; CI: 1.08, 2.17), driven by exposure to toluene (OR=1.67; CI: 1.02, 2.73). No association was seen for any paternal occupational exposure to solvents with the exception of exposure to perchloroethylene in Finland (OR=2.42; CI: 1.32, 4.41). CONCLUSIONS: This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000461476600003 |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22564 |
专题 | 资源环境科学 |
作者单位 | 1.Int Agcy Res Canc, Sect Environm & Radiat, 150 Cours Albert Thomas, F-69372 Lyon 08, France; 2.Deutsch Krebsforsch Zentrum DKFZ, Div Canc Epidemiol, Heidelberg, Germany; 3.Ctr Leon Berard, Dept Canc & Environm, Lyon, France; 4.Univ Claude Bernard Lyonl, 43 Blvd 11 Novembre 1918, F-1918 Villeurbanne, France; 5.Finnish Canc Registry, Inst Stat & Epidemiol Canc Res, Helsinki, Finland; 6.Univ Tampere, Fac Social Sci, Tampere, Finland; 7.Canc Registry Norway, Oslo, Norway; 8.Natl Inst Occupat Hlth, Oslo, Norway; 9.Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden; 10.Danish Canc Soc Res Ctr, Copenhagen, Denmark; 11.FIOH, Helsinki, Finland; 12.Karolinska Inst, Inst Environm Med, Unit Occupat Med, Stockholm, Sweden; 13.Int Res & Res Training Ctr Endocrine Disrupt Male, Copenhagen, Denmark |
推荐引用方式 GB/T 7714 | Le Cornet, Charlotte,Fervers, Beatrice,Pukkala, Eero,et al. Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(6). |
APA | Le Cornet, Charlotte.,Fervers, Beatrice.,Pukkala, Eero.,Tynes, Tore.,Feychting, Maria.,...&Schuz, Joachim.(2017).Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study.ENVIRONMENTAL HEALTH PERSPECTIVES,125(6). |
MLA | Le Cornet, Charlotte,et al."Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study".ENVIRONMENTAL HEALTH PERSPECTIVES 125.6(2017). |
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